摘要
目的了解舌下免疫治疗(SLIT)各年龄段变应性鼻炎(AR)的短期疗效。方法收集2020年11月至2021年9月蚌埠市第三人民医院确诊并接受SLIT治疗的全部AR患者230例的资料,分析患者的分布特征;随机选取其中的93例患者,根据年龄分为儿童组、青少年及成年人组,记录并比较患者SLIT治疗前、治疗后4个月的总鼻症状评分(TNSS)变化,以评估该治疗方法的短期疗效。皮肤点刺试验用于确诊患者的过敏状态,TNSS变化用于评估SLIT治疗的疗效。结果接受治疗的患者年龄跨度较大(3~71岁),但平均年龄仅为17.70岁;93例患者完成了随访,分为儿童组50例、青少年及成年人组43例,两组治疗后4个月的TNSS评分均明显低于治疗前[(3.66±1.69)分比(6.60±1.96)分,(3.49±1.72)分比(6.28±2.28)分],差异均有统计学意义(均P<0.001),而两组间治疗前后TNSS差异均无统计学意义(均P>0.05)。结论SLIT在AR患者中的使用趋于年轻化,短期的SLIT治疗对AR患者是有效的,且SLIT的疗效在各种年龄AR患者无明显差异。
Objective To investigate the short-term efficacy of sublingual immunotherapy in patients with allergic rhinitis of all ages.Methods The data of 230 patients with allergic rhinitis of all ages who received sublingual immunotherapy in The Third People's Hospital of Bengbu from November 2020 to September 2021 were included in this study.Patient distribution characteristics were analyzed.Ninety-three patients were randomly selected and divided into child,adolescent,and adult groups according to different ages.Total nasal symptom scores measured before and 4 months after sublingual immunotherapy were compared among patients of different ages to evaluate the short-term efficacy of sublingual immunotherapy.The skin prick test was used to determine the allergic state of patients.Change in total nasal symptom score after treatment relative to that before treatment was used to evaluate the efficacy of sublingual immunotherapy.Results The age range of patients receiving sublingual immunotherapy was large(3-71 years),but the average age was only 17.70 years.Ninety-three patients were followed up,including 50 children and 43 adolescents or adults.After 4 months of sublingual immunotherapy,total nasal symptom score in children and adolescents or adults were significantly decreased compared with those before treatment[(3.66±1.69)points vs.(6.60±1.96)points,(3.49±1.72)points vs.(6.28±2.28)points,both P<0.001].Before and after treatment,there was no significant difference in total nasal symptom score between children and adolescents or adults(both P>0.05).Conclusion Patients with allergic rhinitis who receive sublingual immunotherapy tend to be young.Short-term sublingual immunotherapy is effective for allergic rhinitis.There is no remarkable difference in the efficacy of sublingual immunotherapy between patients with allergic rhinitis of all ages.
作者
唐旋
杨立新
李东海
Tang Xuan;Yang Lixin;Li Donghai(Department of Otolaryngology,The Third People's Hospital of Bengbu,Bengbu 233000,Anhui Province,China;Department of Otolaryngology,The First Affiliated Hospital of Anhui University of Science and Technology,Huainan 232007,Anhui Province,China)
出处
《中国基层医药》
CAS
2022年第12期1859-1861,共3页
Chinese Journal of Primary Medicine and Pharmacy
关键词
鼻炎
变应性
常年性
舌下免疫疗法
年龄分布
疗效比较研究
螨感染
Rhinitis,Allergic,perennial
Sublingual immunotherapy
Age distribution
Comparative effectiveness research
Mite infestations
