摘要
目的探讨睑板腺功能障碍(MGD)型干眼与螨虫感染的相关性及药物治疗的效果评估。方法选取2019年6月至2020年5月在山西白求恩眼科门诊确诊为MGD型干眼患者90例(90眼)为试验组,其中男性42例,女性48例,年龄18~60岁,平均(42±7)岁。按照干眼的严重程度分3组,选取无MGD健康人30名(30眼)作为对照组,检测2组患者的螨虫的感染率。试验组中选取螨虫感染的MGD型干眼患者55例,其中男性24例,女性31例,年龄31~58岁,平均(40±5)岁,随机分成2组,组A予局部睑板腺按摩+妥布霉素治疗,辅助每日热敷30 min。组B在此治疗基础上加用茶树油清洁湿巾(医用冷敷护眼敷料)。治疗4周后检测螨虫清除率及干眼好转率。结果 MGD型干眼3组患者与对照组比较,螨虫感染率差异有统计学意义(F=5.43,P=0.017)。对螨虫感染的MGD型干眼药物治疗的结果比较,A、B 2组患者治疗前后裂隙灯下观察临床体征评分比较,2组间差异有统计学意义(t=-2.417,P=0.008)。干眼好转率差异有统计学意义(χ^(2)=3.14,P=0.026);螨虫清除率的比较,2组差异有统计学意义(χ^(2)=5.61,P=0.004)。结论在MGD型干眼患者中,螨虫感染率较健康人群高。并随着干眼程度的加重,螨虫感染率也逐渐增高。在综合药物治疗时,加用茶树油清洁湿巾(医用冷敷护眼敷料)杀螨效果更好,对于改善干眼的症状及眼部体征的评分均优于对照组。
Objective To investigate the correlation between dry eyes with meibomian gland dysfunction(MGD)and mite infection,and to evaluate the effect of drug treatment.Methods A prospective cohort study was conducted.Ninety patients(90 eyes)diagnosed with MGD-type dry eyes at Department of Ophthalmology,Shanxi Bethune Hospital between June 2019 and May 2020 were recruited in the study group,including 42 males and 48 females,aged 18~60 years old[mean age(42±7)years old].According to the severity of dry eyes,all patients were divided into 3 subgroups.Thirty normal subjects(30 eyes)without MGD were included in the control group.The infection rate of mites in the two groups was measured.In the study group,55 patients with MGD-type dry eyes and mite infection were selected,including 24 males and 31 females,aged 31~58 years old[mean age(40±5)years old],and were randomly divided into two subgroups.Group A was treated with local meibomian gland massage+Tobramycin,assisted by daily hot compress for 30 minutes.In addition,group B was treated with tea tree oil cleaning wet wipes(medical cold compress dressing for eye protection).At 4 weeks after the treatment,the mite removal rate and dry eyes improvement rate were determined.Results There was statistically significant difference in the mite infection rate between the 3 groups of MGD-type dry eyes and the control group(F=5.43,P=0.017).The results of drug treatment for patients with MGD-type dry eyes and mite infection were compared.There was statistically significant difference in the scores of clinical signs under slit-lamp examination at baseline and after the treatment between groups A and B(t=-2.417,P=0.008).There were statistically significant difference in the improvement rate of dry eyes(χ^(2)=3.14,P=0.026)and mite removal rate(χ^(2)=5.61,P=0.004)between the two groups.Conclusion In patients with MGD-type dry eyes,the rate of mite infection is higher than that in normal subjects.The rate of mite infection increases along with the aggravating dry eyes.In the comprehensive
作者
张伟亮
曹小琴
Zhang Weiliang;Cao Xiaoqin(Department of Ophthalmology,Shanxi Bethune Hospital,Taiyuan 030032,China;不详)
出处
《中国药物与临床》
CAS
2021年第12期2039-2042,共4页
Chinese Remedies & Clinics
关键词
睑板腺
螨感染
茶树油
干眼病
Meibomian glands
Mite infestations
Tea tree
Xerophthalmia
