摘要
目的:观察经阴道超声介入引导局部注射氨甲蝶呤治疗子宫瘢痕妊娠患者的效果。方法:选取2016年5月至2020年12月该院收治的78例子宫瘢痕妊娠患者进行前瞻性研究,按照随机数字表法分为对照组和观察组各39例。观察组采用经阴道超声介入引导下氨甲蝶呤局部注射治疗,对照组予以氨甲蝶呤单次肌内注射治疗,比较两组疗效、血人绒毛促性腺激素(HCG)恢复正常时间、住院时间、附件肿物完全吸收时间、治疗前后血HCG水平和不良反应发生率。结果:观察组治疗总有效率为92.3%,明显高于对照组的74.4%,差异有统计学意义(P<0.05);观察组HCG恢复正常时间、住院时间、附件肿物完全吸收时间均短于对照组,差异有统计学意义(P<0.05);治疗后,两组血HCG水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率为10.3%,明显低于对照组的30.8%,差异有统计学意义(P<0.05)。结论:经阴道超声介入引导局部注射氨甲蝶呤治疗子宫瘢痕妊娠患者可提高治疗总有效率,缩短血HCG恢复正常时间、住院时间和附件肿物完全吸收时间,降低血HCG水平和不良反应发生率,优于氨甲蝶呤单次肌内注射治疗效果。
Objective:To observe effects of local injection of Methotrexate guided by transvaginal ultrasound in treatment of patients with uterine scar pregnancy.Methods:A prospective study was conducted on 78 patients with uterine scar pregnancy admitted to the hospital from May 2016 to December 2020.They were divided into control group and observation group according to the random number table method,39 cases in each.The observation group was treated with local injection of Methotrexate guided by transvaginal ultrasound,while the control group was treated with single intramuscular injection of Methotrexate.The efficacy,the blood human chorionic gonadotropin(HCG)recovery time,the hospitalization time,the complete absorption time of adnexal masses,the blood HCG levels before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of treatment in the observation group was 92.3%,which was significantly higher than 74.4%in the control group,and the difference was statistically significant(P<0.05).The HCG recovery time,the hospitalization time and the complete absorption time of adnexal masses in the observation group were shorter than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the blood HCG levels of the two groups were lower than those before the treatment,that of the observation group was lower than that of the control group,and the differences were statistically significant(P<0.05).The incidence of adverse reactions of the observation group was 10.3%,which was lower than 30.8%in the control group,and the difference was statistically significant(P<0.05).Conclusions:Local injection of Methotrexate guided by transvaginal ultrasound in the treatment of the patients with uterine scar pregnancy can improve the total effective rate of treatment,shorten the blood HCG recovery time,the hospitalization time and the complete absorption time of adnexal masses,and reduce the blood HCG levels and the
作者
马凤英
MA Fengying(Pingyu County Maternal and Child Health Hospital,Zhumadian 463400 Henan,China)
出处
《中国民康医学》
2022年第24期22-24,共3页
Medical Journal of Chinese People’s Health
关键词
氨甲蝶呤
经阴道超声介入
子宫瘢痕妊娠
HCG
不良反应
Methotrexate
Transvaginal ultrasound intervention
Uterine scar pregnancy
HCG
Adverse reaction
