摘要
目的了解山东省青岛市18岁及以上居民高尿酸血症(HUA)的患病情况及影响因素,为制定成年人群HUA防控措施提供科学依据。方法于2019年5月-2020年9月采用多阶段分层随机抽样方法,抽取6240名青岛市18岁及以上常住居民为调查对象,进行问卷调查(基本信息和行为危险因素)、体格测量和生化指标测定。使用SPSS 25.0软件对青岛市成年人HUA患病情况及其影响因素进行分析。结果本研究最终纳入有效样本6040份。2020年青岛市18岁及以上居民的血尿酸水平为(345.89±95.03)μmol/L,男性血尿酸水平高于女性(t=44.052,P<0.001)。人群中总HUA患病率为28.92%,标化患病率为29.56%;男性患病率(35.67%)高于女性(22.22%),差异有统计学意义(χ^(2)=132.886,P<0.001);男性、女性标化患病率分别为37.34%和21.65%。有HUA者的身体质量指数(BMI)、腰围、收缩压、舒张压、血尿酸、口服葡萄糖耐量试验(OGTT)服糖后2 h血糖(2 hPG)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)水平均高于无HUA者,差异有统计学意义(P均<0.001),而高密度脂蛋白胆固醇(HDL-C)水平则低于无HUA者,差异有统计学意义(P<0.001)。多因素非条件logistic回归分析结果显示,男性(O R=1.524,95%CI:1.298~1.789)、饮酒(O R=1.183,95%CI:1.026~1.364)、高BMI(超重O R=2.057,95%CI:1.763~2.400;肥胖O R=3.011,95%CI:2.544~3.564)、患高血压(O R=1.293,95%CI:1.119~1.495)、高TG血症(O R=2.390,95%CI:2.069~2.760)、高LDL-C血症(O R=1.441,95%CI:1.097~1.893)是HUA发生的独立危险因素。结论山东省青岛市成年人HUA患病率较高,男性、饮酒、超重、肥胖、患高血压、高TG血症和高LDL-C血症是HUA发生的独立危险因素。
Objective To understand the prevalence and influencing factors of hyperuricemia(HUA)in residents aged 18 years and above in Qingdao city,Shandong province,so as to provide a scientific basis for the development of preventive and control measures for HUA in the adult population.Methods A multistage stratified random sampling method was used to select 6240 permanent residents aged 18 years and older in Qingdao city from May 2019 to September 2020 for questionnaire surveys(basic information and behavioral risk factors),physical measurements and biochemical index measurements.The prevalence of HUA and its influencing factors among adults in Qingdao city were analyzed using SPSS25.0 software.Results A final valid sample of 6040 was included in this study.The median level of uric acid was 345.89±95.03μmol/L among residents aged 18 years and above in Qingdao city,which was higher in male residents than in females(t=44.052,P<0.001).The overall prevalence of HUA was 28.92%and 29.56%after standardization;The prevalence was higher in men(35.67%)than in women(22.22%),and the difference was statistically significant(χ^(2)=132.886,P<0.001).Body mass index(BMI),waist circumference,systolic blood pressure,diastolic blood pressure,the blood uric acid,2-hour plasma glucose(2 hPG),total cholesterol,triglyceride and low density lipoprotein cholesterol levels in the HUA group were significantly higher than those in the non-HUA group(all P<0.001).While high density lipoprotein cholesterol level in the HUA group was significantly lower than that in the non-HUA group(P<0.001).Unconditional multivariate logistic regression analysis showed that men(O R=1.524,95%CI:1.298-1.789),alcohol consumption(O R=1.183,95%CI:1.026-1.364),higher BMI(overweight O R=2.057,95%CI:1.763-2.400;obesity O R=3.011,95%CI:2.544-3.564),hypertension(O R=1.293,95%CI:1.119-1.495),hypertriglyceridemia(O R=2.390,95%CI:2.069-2.760)and high low density lipoproteinemia(O R=1.441,95%CI:1.097-1.893)were independent risk factors for HUA.Conclusion The prevalence of HUA in
作者
赵园园
李斐斐
张金太
马海燕
汪韶洁
王文苑
张华
ZHAO Yuan-yuan;LI Fei-fei;ZHANG Jin-tai;MA Hai-yan;WANG Shao-jie;WANG Wen-yuan;ZHANG Hua(Department of Chronic and Non-communicable Disease Control and Prevention,Qingdao Center for Disease Control and Prevention,Qingdao,Shandong 266033,China;Department of Chronic and Non-communicable Disease Control and Prevention,West Coast New District Center for Disease Control and Prevention;Department of Chronic and Non-communicable Disease Control and Prevention,Chengyang District Center for Disease Control and Prevention)
出处
《预防医学论坛》
2022年第11期806-811,815,共7页
Preventive Medicine Tribune
基金
山东省青岛市医疗卫生重点学科建设项目(2020)
山东省青岛市医药科研指导计划项目(2019-WJZD149)。
关键词
尿酸
高尿酸血症
影响因素
患病率
Uric acid
Hyperuricemia
Influencing factors
Prevalence
