摘要
抑郁症是一种常见的情感性精神障碍,患者不仅在情绪上表现出持续的低落、悲观、冷漠等,同时在躯体上常伴有食欲不振、便秘等胃肠道症状。肠道菌群在抑郁症发病机制中潜在的生物学作用已受到广泛关注,其在肠与脑相互作用中扮演着重要角色,不仅影响肠道屏障功能,还可以通过调控肠道微生物-肠-脑轴维持宿主机体的稳态。近年来,中药在预防和治疗抑郁症等神经精神系统疾病时,具有效果显著且不良反应较小的特点,且中药通过调节肠道菌群结构、减少移位以及维持菌群正常功能等方面发挥抗抑郁作用的研究已被广泛关注。本综述主要通过调研近年来相关文献资料,从中药单体、单味药及复方多种角度探讨中药对肠道菌群的改善作用,从中药对肠道菌群结构的矫正作用、调节免疫作用、进行菌群移植以及对其代谢物调节等不同层次发挥抗抑郁的作用及其机制进行由浅入深的总结。本综述将为深入阐释肠道菌群在抑郁症的发生机制及中药抗抑郁的作用机制研究提供依据。
Depression is a common emotional mental disorder.Patients not only continuously showed depression,pessimism and apathy in mood,but also have gastrointestinal symptoms such as anorexia and constipation in body.Widely attention has been also received in the potential biological role of gut microbiota in the pathogenesis of depression.It plays an important role in the interaction between the intestine and the brain,not only affecting the intestinal barrier function,but also maintaining the homeostasis of host through the microbiota-gut-brain axis.In recent years,the traditional Chinese medicine(TCM) has the advantages of obvious therapeutic effects and few side effects when treating neuropsychiatric diseases,such as depression.The pharmacological mechanism of TCM exerting antidepressant effects by regulating the structure of gut microbiota,reducing displacement,and maintaining the normal function of gut microbiota has been also widely concerned.By investigating the relevant literature in recent years,this paper summarizes the antidepressant effect of TCM in different directions such as Chinese medicine monomer,single medicine and compound medicine.And this paper reviews the antidepressant effects and mechanisms of TCM at different levels,such as the correction of gut microbiota structure,the regulation of immunity,the transplantation of gut microbiota and the regulation of its metabolites.This paper will provide a basis for further explaining the mechanism of gut microbiota in depression and the mechanism of antidepressant effect of TCM.
作者
王琦
赵映霞
赵慧亮
吴振宁
秦雪梅
田俊生
WANG Qi;ZHAO Ying-xia;ZHAO Hui-liang;WU Zhen-ning;QIN Xue-mei;TIAN Jun-sheng(Modern Research Center for Traditional Chinese Medicine,Shanxi University,Taiyuan 030006,China;Shanxi Key Laboratory of Active Constituents Research and Utilization of TCM,Taiyuan 030006,China)
出处
《药学学报》
CAS
CSCD
北大核心
2022年第12期3494-3501,共8页
Acta Pharmaceutica Sinica
基金
山西省基础研究计划项目(202103021224026)。
关键词
肠道菌群
抑郁症
中药
微生物-肠-脑轴
菌群代谢物
gut microbiota
depression
traditional Chinese medicine
microbiota-gut-brain axis
microbial metabolite
