摘要
目的 对小槐花(Ohwia caudata(Thunberg)H.Ohashi)茎的化学成分进行研究,为丰富其物质基础和开发利用奠定基础。方法 采用加热回流提取法对小槐花干燥茎进行提取,综合应用多种色谱法对小槐花茎提取物的化学成分进行分离纯化,并结合化合物理化性质与波谱解析等方法进行结构鉴定。结果与结论从小槐花干燥茎的体积分数70%乙醇提取物中分离鉴定出15个酚酸类化合物,分别为isotachioside(1)、4-羟基-3-甲氧基苯基β-D-吡喃葡萄糖苷(2)、markhamioside F(3)、canthoside C(4)、leonuriside A(5)、3,5-二甲氧基-4-羟基-苯酚-1-O-β-D-吡喃葡萄糖苷(6)、canthoside B(7)、triandrin(8)、dihydroconiferyl alcohol glucoside(9)、4-O-(2-hydroxy-1-hydroxymethylethyl)-dihydroconiferyl alcohol(10)、(-)-(2R)-1-O-(β-D-glucopyranosyl)-2-[2-methoxy-4-(ω-hydroxypropyl)-phenoxyl]-propan-3-ol(11)、trans-isoconiferin(12)、松柏苷(13)、ferulic acid(14)、紫丁香苷(15)。其中,化合物1~5、7~13和15为首次从小槐花属植物中分离得到。
The dried stems of Ohwia caudata(Thunberg)H.Ohashi were refluxed by 70%EtOH,and then the extracts were isolated through using various chromatographic methods.As results,fifteen phenolic constituents were obtained and identified by using various spectroscopic methods combining with their physicochemical property.They were isotachioside(1),4-hydroxy-3-methoxyphenylβ-D-glucopyranoside(2),markhamioside F(3),canthoside C(4),leonuriside A(5),3,5-dimethoxy-4-hydroxyphenyl-1-O-β-D-glucopyranoside(6),canthoside B(7),triandrin(8),dihydroconiferyl alcohol glucoside(9),4-O-(2-hydroxy-1-hydroxymethylethyl)-dihydroconiferyl alcohol(10),(-)-(2R)-1-O-(β-D-glucopyranosyl)-2-[2-methoxy-4-(ω-hydroxypropyl)-phenoxyl]-propan-3-ol(11),trans-isoconiferin(12),coniferin(13),ferulic acid(14),and syringin(15).Among them,compounds 1-5,7-13 and 15 were isolated from the Ohwia genus for the first time.This study might enrich the phytochemistry of O.caudata and establish foundation for its development and utilization.
作者
杨丁山
阮静雅
韩玉
张倩倩
王涛
张祎
YANG Ding-shan;RUAN Jing-ya;HAN Yu;ZHANG Qian-qian;WANG Tao;ZHANG Yi(Key Laboratory of Traditional Chinese Medicinal Chemistry and Analytical Chemistry of Tianjin,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China)
出处
《中国药物化学杂志》
CAS
CSCD
2022年第11期862-869,共8页
Chinese Journal of Medicinal Chemistry
基金
国家自然科学基金面上项目(82074118)。
关键词
小槐花
酚酸类成分
提取分离
结构鉴定
Ohwia caudata(Thunberg)H.Ohashi
phenolic constituents
extraction and isolation
structural identification
