摘要
目的观察养阴利咽汤联合匹多莫德口服溶液治疗阴虚火旺型小儿疱疹性咽峡炎的临床疗效。方法将118例阴虚火旺型疱疹性咽峡炎患儿按照随机抽签法分为2组,对照组59例予匹多莫德口服溶液治疗,治疗组59例在对照组基础上加用养阴利咽汤治疗。2组均治疗1周后统计疗效,比较2组治疗后发热、疱疹、咽痛消退时间及总治疗时间情况,比较2组治疗前后血清炎症因子白细胞介素1β(IL-1β)、肿瘤坏死因子α(TNF-α)及集落刺激因子1(CSF-1)水平变化情况,比较2组治疗前后免疫功能指标T淋巴细胞亚群CD3^(+)、CD4^(+)、CD8^(+)及CD4^(+)/CD8^(+)水平变化情况,比较2组治疗期间的不良反应发生情况。结果治疗组总有效率91.53%(54/59),不良反应总发生率11.86%(7/59),对照组分别为76.27%(45/59)、8.47%(5/59),治疗组总有效率高于对照组(P<0.05),且2组不良反应总发生率比较差异无统计学意义(P>0.05)。治疗组治疗后发热、疱疹、咽痛消退时间及总治疗时间均短于对照组(P<0.05)。与本组治疗前比较,2组治疗后IL-1β、TNF-α及CSF-1水平均降低(P<0.05),且治疗组治疗后IL-1β、TNF-α及CSF-1水平均低于对照组(P<0.05)。与本组治疗前比较,2组治疗后T淋巴细胞亚群CD3^(+)、CD4^(+)及CD4^(+)/CD8^(+)均升高(P<0.05),CD8^(+)水平均降低(P<0.05),且治疗组治疗后CD3^(+)、CD4^(+)及CD4^(+)/CD8^(+)均高于对照组(P<0.05),CD8^(+)水平低于对照组(P<0.05)。结论养阴利咽汤联合匹多莫德口服溶液治疗阴虚火旺型小儿疱疹性咽峡炎临床疗效确切,可有效促进临床症状消退,缩短治疗时间,且治疗安全性好,其作用机制可能与抑制炎性反应,调节免疫功能有关。
Objective To observe the clinical efficacy of Yangyin Liyan Decoction combined with pidotimod oral solution for infantile herpetic angina of asthenic yin causing excessive pyrexia.Methods Totally 118 cases of infantile herpetic angina(asthenic yin causing excessive pyrexia)were randomized 1:1 to receive pidotimod oral solution(the control group)or Yangyin Liyan Decoction+pidotimod oral solution(the treatment group)for 1 week.The aim was to compare the regression time and overall treatment time of fever,herpes,pharyngalgia;serum inflammatory factors(Interleukin-1β[IL-1β],Tumor Necrosis Factor-α[TNF-α],Colony-stimulating factor-1[CSF-1]),T lymphocyte subsets(CD3^(+),CD4^(+),CD8^(+)and CD4^(+)/CD8^(+)).The curative effect and adverse reaction were assessed.Results The overall effective rate in the treatment group was better than that in the control group(91.53%[54/59]vs 76.27%[45/59],[P<0.05],respectively).The difference was not statistically significant in adverse reactions between the treatment group and the control group(11.86%[7/59]vs 8.47%[5/59],[P<0.05],respectively).After treatment,the regression time and overall treatment time to fever,herpes,pharyngalgia were shorter in the treatment group than in the control group(P<0.05);IL-1β,TNF-αand CSF-1 in the both groups were decreased(P<0.05),the reduction in the treatment group was more prevalent relative to the control group(P<0.05);CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)in the both groups were increased(P<0.05),while CD8^(+)was decreased(P<0.05);higher CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)and lower CD8^(+)were detected in the treatment group than those in the control group(all P<0.05).Conclusion For infantile herpetic angina of asthenic yin causing excessive pyrexia,the two combinations have a definite curative effect,which can effectively promote the regression of clinical symptoms,shorten the treatment time by inhibiting the inflammatory response and regulating the immune function,and with good safety.
作者
蒋芸
胡彩枫
JIANG Yun;HU Caifeng(Chinese Pharmacy,Wujin Hospital of Traditional Chinese Medicine,Changzhou,Jiangsu 213161;Department of Otorhinolaryngology,Wujin Hospital of Traditional Chinese Medicine,Changzhou,Jiangsu 213161)
出处
《河北中医》
2022年第10期1652-1655,共4页
Hebei Journal of Traditional Chinese Medicine
关键词
疱疹性咽峡炎
儿童
阴虚火旺
中西医结合疗法
Herpetic angina
Children
Asthenic yin causing excessive pyrexia
Integrated traditional Chinese and Western medicine therapy
