摘要
目的探究枸橼酸咖啡因与氨茶碱治疗早产儿原发性呼吸暂停(AOP)的疗效与安全性差异。方法研究对象选取为睢县妇幼保健院2019年3月至2021年5月收治的AOP患儿92例,采用数字表法随机将以上患儿分为A、B两组,各46例,A组患儿采用枸橼酸咖啡因治疗,B组患儿则采用氨茶碱治疗。对比两组患儿的疗效,对比两组患儿的用氧时间、无创通气时间,对比两组患儿的平均住院时间,出生后3周内的体重平均增加速度,出院时的体重平均增加速度及两组患儿的不良反应发生率。结果A组患儿治疗有效率(89.13%)(41/46),显著高于B组患儿(71.74%)(33/46),差异有统计学意义(P<0.05)。A组患儿用氧时间、无创通气时间均低于B组患儿,差异有统计学意义(P<0.05)。两组患儿的平均住院时间的数据差异无统计学意义(P>0.05);A组患儿出生后3周内的体重平均增加速度、出院时的体重平均增加速度均低于B组患儿,差异有统计学意义(P<0.05)。两组患儿的视网膜病变发生率对比,差异无统计学意义(P>0.05),但A组高血糖、心动过速、支气管肺发育不良、喂养不耐受发生率均低于B组,差异有统计学意义(P<0.05)。结论枸橼酸咖啡因治疗AOP的疗效优于氨茶碱,能够缩短患儿的无创通气治疗时间,且能够有效控制不良反应发生。
Objective To explore the efficacy and safety of caffeine citrate and aminophylline in the treatment of apnea of prematurity(AOP) in premature infants. Methods A total of 92 children with AOP admitted to Suixian Maternal and Child Health Hospital from March 2019 to May 2021 were selected as subjects. The above children were randomly divided into A and B groups with 46 cases each by random table method. Group A was treated with caffeine citrate, group B was treated with aminophylline. The efficacy, oxygen duration, and non-invasive ventilation duration of the two groups were compared, as well as the average length of hospital stay, the average rate of weight gain within 3 weeks after birth, the average rate of weight gain at discharge, and the incidence of adverse reactions in the two groups. Results The effective rate of group A(89.13%)(41/46)was significantly higher than that of group B(71.74%)(33/46), and the difference was statistically significant(P < 0.05).The oxygen duration and non-invasive ventilation duration of group A were lower than those of group B, and the difference was statistically significant(P < 0.05). There was no significant difference in the mean length of hospital stay between the two groups(P > 0.05). The average weight increase rate in group A within 3 weeks after birth and the average weight increase rate at discharge was lower than those in group B, and the difference was statistically significant(P < 0.05). There was no statistical significance in the incidence of retinopathy between the two groups(P > 0.05), but the incidence of hyperglycemia, tachycardia,bronchopulmonary dysplasia, and feeding intolerance in group A was lower than that in group B, with statistical significance(P < 0.05). Conclusion Caffeine citrate is better than aminophylline in the treatment of AOP, which can shorten the duration of non-invasive ventilation therapy and effectively control the occurrence of adverse reactions.
作者
曲恩慧
QU Enhui(Department of Neonatology,Suixian Matermal and Child Health Hospital,Shangqiu Henan 476900,China)
出处
《临床研究》
2023年第1期42-44,共3页
Clinical Research
关键词
早产儿原发性呼吸暂停
枸橼酸咖啡因
氨茶碱
疗效
安全性
apnea of prematurity in premature infants
caffeine citrate
aminophylline
efficacy,security
