摘要
目的:研究不同维持剂量枸橼酸咖啡因治疗早产儿原发性呼吸暂停的疗效及不良反应。方法:选择2018年1月~2019年12月本院纳入的200例原发性呼吸暂停早产儿作为研究对象,按照随机分层法分成研究组和对照组,各100例。研究组给予15mg/kg的维持剂量枸橼酸咖啡因进行治疗,对照组给予5mg/kg的维持剂量枸橼酸咖啡因进行治疗。评价两组用药后的临床疗效,记录两组治疗后3天之内的呼吸暂停次数、发作维持时长、症状消退时长以及住院时长,比较两组治疗前和治疗后的潮气量、达峰时间比、达峰容积比、每分通气量、血氧分压(PaO_(2))、二氧化碳分压(PaCO2)和病情严重程度分级,并观察两组治疗期间不良反应(包括心动过速、脑出血、高血压、喂养不耐受、电解质紊乱、烦躁不安等)发生情况。结果:研究组总有效率(92.00%)高于对照组(77.00%,P<0.05)。治疗后,研究组呼吸暂停次数、发作维持时长、症状消退时长、住院时长少于对照组,潮气量、达峰时间比、达峰容积比、每分通气量、PaO_(2)水平高于对照组,PaCO_(2)水平低于对照组,疾病严重程度分级优于对照组(P<0.05)。两组不良反应发生率比较无统计学差异(P>0.05)。结论:高维持剂量的枸橼酸咖啡因效果更为显著,能有效改善肺功能和血气指标,减少呼吸暂停的发作次数,减轻病情严重程度,且不会增加不良反应发生率,安全性较高,为预后提供保障。
Objective:To study the efficacy and adverse reactions of different maintenance doses of caffeine citrate in the treatment of primary apnea in preterm infants.Methods:A total of 200 premature infants with primary apnea treated from January 2018 to December 2019 in our hospital were selected as the research subjects.According to random stratification method,they were divided into study group and control group,with 100 cases in each group.The study group was treated with 15 mg/kg maintenance dose of caffeine citrate,and the control group was treated with 5 mg/kg maintenance dose of caffeine citrate.The clinical efficacy of the two groups was evaluated.The times of apnea,the duration of attack maintenance,the duration of symptom regression and the length of hospitalization in the two groups within 3 days after treatment were recorded.The tidal volume,peak time ratio,peak volume ratio,minute ventilation,partial pressure of oxygen(PaO_(2)),partial pressure of carbon dioxide(PaCO2)and disease severity grade were compared between the two groups before and after treatment.Adverse reactions(including tachycardia,intracerebral hemorrhage,hypertension,feeding intolerance,electrolyte disorder,irritability,etc.)were observed the two groups during the treatment.Results:The total effective rate of the study group(92.00%)was higher than that of the control group(77.00%,P<0.05).After treatment,the times of apnea,duration of attack maintenance,duration of symptom regression and length of hospitalization in the study group were less than those in the control group;the tidal volume,peak time ratio,peak volume ratio,minute ventilation and PaO_(2)level were higher than those in the control group;the PaCO2 level was lower than that in the control group;the disease severity grade was better than that in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:The effect of high maintenance dose of caffeine citrate is more significant.It can effectively i
作者
程雪莲
李德亮
朱萍
CHENG Xue-lian;LI De-liang;ZHU Ping(Neonatal Intensive Care Unit,Nanyang Central Hospital,Nanyang 473000,China)
出处
《中国合理用药探索》
2022年第2期81-87,共7页
Chinese Journal of Rational Drug Use
