摘要
结直肠癌是我国第3大常见癌症,发病率、死亡率逐年上升。由于耐药导致结直肠癌化疗失败的报道不断增多,迫切需要寻找新的药物作为化疗药物的增敏剂。以中药活性成分为研究重点,发现姜黄素、白藜芦醇、人参皂苷等中药活性成分可以通过调控相关蛋白表达、自噬、上皮间充质转化、癌症干细胞、有氧糖酵解等途径逆转结直肠癌耐药性。对逆转结直肠癌耐药性的中药活性成分及其药理作用机制加以总结,以期为结直肠癌治疗提供更多选择。
Colorectal cancer is the third most common cancer in China. Its morbidity and mortality are increasing year by year. Due to the increasing reports of chemotherapy failure of colorectal cancer caused by drug resistance, it is urgent to find new drugs to improve the efficacy of chemotherapy drugs. More and more scholars began to focus on the active components of traditional Chinese medicine. Curcumin, resveratrol, ginsenosides and other active ingredients of traditional Chinese medicine can reverse the drug resistance of colorectal cancer by regulating the expression of related proteins, autophagy, epithelial-mesenchymal transformation, cancer stem cells and aerobic glycolysis. The active components of traditional Chinese medicine that reverse drug resistance of colorectal cancer and their pharmacological mechanism were reviewed, in order to provide more theoretical reference for colorectal cancer chemotherapy.
作者
殷涛涛
方奕雄
惠菁华
雷霆
YIN Taotao;FANG Yixiong;HUI Jinghua;LEI Ting(Shaanxi University of Traditional Chinese Medicine,Xianyang 712000,China;Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine,Xianyang 712000,China)
出处
《药物评价研究》
CAS
2022年第11期2357-2363,共7页
Drug Evaluation Research
基金
陕西省自然科学基础研究计划面上项目(2021JM-474)
咸阳市中青年科技领军人才项目(2020K04-01)。
