摘要
目的 探析紫癜性肾炎的危险因素,提高患者的临床及预后治疗效果。方法 随机抽取本院收治的紫癜性肾炎患者37例,抽取时间为2015年1月至2020年9月。所有纳入研究对象均进行正常治疗3个月后,根据患者的治疗情况进行分组,即肾病完全缓解组和肾病未缓解组,对两组患者的基础性资料进行临床分析,探析其影响紫癜性肾炎进展的危险因素。结果 经治疗发现,37例紫癜性肾炎患者中肾病完全缓解及未缓解患者分别为27例和10例;两组患者中年龄、24 h尿蛋白定量、血肌酐水平、血白蛋白水平相比,差异有统计学意义(P<0.05);血清IgA、C反应蛋白(CRP)、血尿程度、性别及是否使用免疫抑制剂治疗等基础性资料对比,差异无统计学意义(P>0.05);以肾病未缓解患者为因变量,经单因素及多因素分析后患者基础性资料中年龄、24 h尿蛋白定量属于影响紫癜性肾炎的危险因素(P<0.05)。结论 临床给予紫癜性肾炎患者在治疗中应该注重关注其年龄、24 h尿蛋白定量,确保患者获取较好的临床治疗及预后效果,同时也可以根据以上相关指标对患者加强预防与治疗。
Objective To explore the risk factors of purpura nephritis, and to improve the clinical and prognosis of patients. Methods A total of 37 patients with purpura nephritis were randomly selected from January 2015 to September 2020. After all the subjects were given normal treatment for 3 months, they were divided into two groups according to their treatment conditions, namely, complete remission group and unresponsive group.The basic data of the two groups were analyzed clinically, and the risk factors affecting the progress of Henoch-Schonlein purpura nephritis were analyzed. Results After treatment, it was found that among 37 patients with purpura nephritis, 27 patients had complete remission and 10 patients had no remission. There were significant differences in age, 24-hour urine protein, serum creatinine level and serum albumin level between the two groups(P<0.05). There was no significant difference between the average value of serum IgA and C-reactive protein(CRP), the degree of hematuria, sex and whether to use immunosuppressant therapy(P>0.05). Taking patients with unresponsive nephropathy as dependent variables,the age and 24-hour urine protein in the basic data of patients were the risk factors of purpura nephritis after univariate and multivariate analysis(P<0.05). Conclusion In the treatment of patients with purpura nephritis, attention should be paid to their age and 24-hour urine protein quantification to ensure better clinical treatment and prognosis. At the same time, we can strengthen prevention and treatment for patients according to the above related indicators.
作者
杨宪辉
YANG Xianhui(Department of Pediatrics,Chaoyang Central Hospital,Chaoyang 122000,China)
出处
《中国医药指南》
2023年第3期83-85,共3页
Guide of China Medicine
关键词
紫癜性肾炎
危险因素
年龄
24
h尿蛋白定量
预后效果
Purpura nephritis
Risk factors
Age
24-hour urine protein quantification
Prognostic effect
