摘要
目的分析紫癜性肾炎(HSPN)患儿合并医院感染病原学特点及危险因素,为HSPN感染的预防及早期诊治提供依据。方法回顾性分析佛山市三水区妇幼保健院于2014年1月至2018年8月期间收治的136例紫癜性肾炎患儿的临床资料,调查患儿感染发生情况,采用单因素分析和Logistic回归分析的方法对感染的影响因素进行统计学分析。结果本组136例患儿中有34例患儿发生感染,发生率为25.00%,感染常见部位为呼吸道感染18例(52.94%)、胃肠道感染7例(20.59%)、泌尿道感染6例(17.65%);常见病原菌为肺炎克雷伯菌13株(36.11%)、大肠埃希菌9株(25.00%)、流感嗜血杆菌7株(19.44%);单因素分析结果显示,感染组与未感染组患儿在年龄、血浆白蛋白、激素使用及住院时间方面比较,差异均有统计学意义(P<0.05);多因素Logistic回归分析结果显示,血浆白蛋白及住院时间为患儿感染的独立危险因素(P<0.05)。结论紫癜性肾炎患儿感染以呼吸道及消化道感染为主,白蛋白水平低及住院时间长是患儿发生感染的独立危险因素。
Objective To analyze the etiology and risk factors of infection in children with Henoch Schonlein purpura nephritis(HSPN), and to provide the evidence for the prevention and early diagnosis and treatment of HSPN with infection. Methods The clinical data of 136 children with Henoch Schonlein purpura nephritis admitted to Sanshui District Maternal and Child Health Hospital of Foshan City from January 2014 to August 2018 was retrospectively analyzed. The incidence of infection in children with the HSPN were investigated. Single factor analysis and logistic regression analysis were used for statistical analysis of the influencing factors for infection. Results Infection occurred in34 of 136 cases, with an incidence of 25.00%. The common infection sites were respiratory tract infection in 18 cases(52.94%), gastrointestinal tract infection in 7 cases(20.59%), urinary tract infection in 6 cases(17.65%). The common pathogenic bacteria were 13 strains of Klebsiella pneumonia(36.11%), 9 strains of Escherichia coli(25.00%), 7 strains of Haemophilus influenzae(19.44%). Single factor analysis showed that there were significant differences in age, serum albumin, hormone use and hospitalization time between the infection group and non-infection group(all P<0.05). Logistic regression analysis results indicated that plasma albumin and hospitalization time were independent risk factors of infection(P<0.05). Conclusion Infection in children with Henoch Schonlein purpura nephritis is mainly caused by respiratory tract and digestive tract infection. Low albumin level and long hospitalization time are independent risk factors for infection.
作者
巫哲谦
张健芳
蔡广创
WUZhe-qian;ZHANG Jian-fang;CAI Guang-chuang(Department of Pediatrics, Sanshui District Maternal and Child Health Hospital of Foshan City, Foshan 528100, Guangdong, CHINA;Department of Pediatrics, Sanshui District People's Hospital of Foshan City, Fosha 528100, Guangdong, CHINA)
出处
《海南医学》
CAS
2019年第14期1858-1860,共3页
Hainan Medical Journal
关键词
过敏性紫癜
紫癜性肾炎
感染
血浆白蛋白
危险因素
Anaphylactoid purpura
Henoch Schonlein purpura nephritis
Infection
Plasma albumin
Risk factors
