摘要
目的探索0~1 h高敏肌钙蛋白I(hs-cTnI)浓度及其变化对于判断非ST段抬高型心肌梗死(NSTEMI)的可行性及准确性,并探讨流程简化的可行性。方法选择2017年1月至2020年9月中国医学科学院阜外医院、中山大学附属第一医院、南京市第一医院急诊科就诊的急性胸痛需排除NSTEMI的患者。对入选患者在就诊时(0 h)、就诊后1 h进行hs-cTnI检测,按照2015年欧洲心脏病学会(ESC)指南推荐的0~1 h的hs-cTnI诊断流程及界值标准进行检验判定,由未参与课题设计且不知道hs-cTnI检测结果的心脏科医师按照急诊常规诊疗流程进行临床判定;以临床判定为金标准,分析指南推荐0~1 h的hs-cTnI浓度及其变化对于判断NSTEMI在中国人群中的诊断效能。对该指南流程进行简化,在不考虑胸痛时间的条件下,利用指南界值进行检验判定,并评估简化流程的诊断效能。结果共纳入1534例患者,年龄(62±12)岁,男952例(62.1%)。其中临床诊断NSTEMI患者402例(26.2%),非NSTEMI患者1132例(73.8%)。依照指南推荐诊断及判定流程,672例(42.8%)患者排除NSTEMI,464例(30.2%)患者诊断NSTEMI,与临床判定一致率为92.4%(1050/1136),排除诊断的灵敏度为99.5%(95%CI:98.0%~99.9%),阴性预测值为99.7%(95%CI:98.8%~99.9%),阴性似然比为0.008(95%CI:0.002~0.335);纳入诊断的特异度为92.6%(95%CI:90.9%~94.0%),阳性预测值为81.9%(95%CI:78.0%~85.2%),阳性似然比为12.739(95%CI:10.356~15.670)。依据简化流程,675例(44.0%)患者排除NSTEMI,463例(30.2%)患者诊断NSTEMI,与临床判定一致率为92.4%(1051/1138),排除诊断的灵敏度为99.3%(95%CI:97.6%~99.8%),阴性预测值为99.6%(95%CI:98.6%~99.9%),阴性似然比为0.012(95%CI:0.004~0.389);纳入诊断的特异度为92.6%(95%CI:90.9%~94.0%),阳性预测值为81.9%(95%CI:78.0%~85.2%),阳性似然比为12.705(95%CI:10.328~15.630)。简化流程判定结果与指南推荐流程相比,其诊断效能差异均无统计学意义(均P>0.05)。结论2015年ESC指南�
Objective To explore the feasibility and accuracy of 0-1 h high sensitivity cardiac troponin I(hs-cTnI)concentration and its changes in judging non-ST segment elevation myocardial infarction(NSTEMI),and to investigate the feasibility of a simplified process.Methods Patients with acute chest pain and suspected NSTEMI who were admitted to the emergency department of Fuwai Hospital,the First Affiliated Hospital of Sun Yat-sen University and Nanjing First Hospital from January 2017 to September 2020 were selected.Hs-cTnI test was carried out for the selected patients at the time of visit(0 h)and 1 h after visit.According to the 0-1 h hs-cTnI diagnostic process and threshold standard recommended by European Society of Cardiology(ESC)guidelines in 2015,the laboratory adjudication was determined.Cardiologists who did not participate in the project design and did not know the results of hs-cTnI test performed the clinical judgment according to the routine diagnosis and treatment process of emergency department.Taking clinical judgment as the gold standard,the diagnostic efficacy of 0-1 h hs-cTnI concentration and its change recommended by the guidelines for judging NSTEMI in Chinese population was analyzed.The guide process was simplified.Under the condition of not considering the time of chest pain,the guideline threshold was used for test and judgement,and the diagnostic efficacy of the simplified process was evaluated.Results A total of 1534 patients were enrolled in the study,aged(62±12)years and 952(62.1%)patients were male.Among them,402 patients(26.2%)were clinically diagnosed as NSTEMI and 1132 patients(73.8%)were diagnosed as non-NSTEMI.According to the diagnosis and determination process recommended by the guidelines,NSTEMI was excluded in 672 patients(42.8%),and 464 patients(30.2%)were diagnosed as NSTEMI.The consistency rate with clinical determination reached 92.4%(1050/1136),the sensitivity of excluding diagnosis was 99.5%(95%CI:98.0%-99.9%),the negative predictive value was 99.7%(95%CI:98.8%-99.9%),and th
作者
高东方
梁岩
蔺亚晖
张国正
杨艳敏
詹红
刘敏
王书奎
刘才冬
朱俊
周洲
Gao Dongfang;Liang Yan;Lin Yahui;Zhang Guozheng;Yang Yanmin;Zhan Hong;Liu Min;Wang Shukui;Liu Caidong;Zhu Jun;Zhou Zhou(Center of Emergency and Critical Care,Fuwai Hospital,National Center for Cardiovascular Diseases,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100037,China;Center of Laboratory Medicine,Fuwai Hospital,National Center for Cardiovascular Diseases,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100037,China;Department of Emergency,the First Affiliated Hospital of Sun Yat-sen University,Guangzhou 510080,China;Department of Laboratory Medicine,Nanjing First Hospital,Nanjing Medical University,Nanjing 210006,China)
出处
《中华医学杂志》
CAS
CSCD
北大核心
2022年第43期3463-3468,共6页
National Medical Journal of China
关键词
肌钙蛋白
高敏肌钙蛋白
急性心肌梗死
中国人群
横断面研究
Troponin
High-sensitivity cardiac troponin
Acute myocardial infarction
Chinese population
Cross-sectional study
