摘要
目的:探究无创正压呼吸机联合常规干预治疗阻塞性睡眠呼吸暂停低通气综合征(OSAHS)合并轻度认知障碍的效果及对认知功能的影响。方法:将2020年1月-2021年12月龙岩人民医院收治的80例OSAHS合并轻度认知障碍根据随机的原则分为对照组40例和观察组40例。对照组进行常规干预治疗,观察组则进行无创正压呼吸机联合常规干预治疗。比较两组OSAHS治疗总有效率、治疗前后的睡眠监测指标[呼吸暂停低通气指数(AHI)、最低血氧饱和度(LSaO)及血氧饱和度<90%次数(SaO<90%次数)]、认知功能相关项目[蒙特利尔认知评估量表(MoCA评分)、脑血流储备及相关血清指标同型半胱氨酸(Hcy)、内皮素-1(ET-1)及8-异前列腺素F(8-iso-PGF)]。结果:治疗1个月及2个月后,观察组的OSAHS治疗总有效率显著高于对照组(P<0.05),治疗前,两组的睡眠监测指标及认知功能相关项目比较,差异均无统计学意义(P>0.05),治疗1个月及2个月后,观察组的睡眠监测指标及认知功能相关项目均显著优于对照组(P<0.05)。结论:无创正压呼吸机联合常规干预治疗OSAHS合并轻度认知障碍的效果较好,且可显著改善患者的认知功能,在OSAHS合并轻度认知障碍患者中的应用价值较高。
Objective:To investigate the effect of noninvasive positive-pressure ventilation combined with routine treatment in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) complicated with mild cognitive impairment and it’s influence on cognitive function.Method:A total of 80 patients with OSAHS complicated with mild cognitive impairment in Longyan People’s Hospital from January 2020 to December 2021were divided into control group and observation group according to the random principle,with 40 cases in each group.The control group was treated with routine treatment,the observation group was treated with noninvasive positive-pressure ventilation combined with routine treatment.Then the total effective rates of OSAHS treatment,sleep monitoring indexes[apnea-hypopnea index (AHI),lowest oxygen saturation (LSaO_(2)) and oxygen saturation<90%(SaO_(2)<90%times)],cognitive function related items[Montreal cognitive assessment (MoCA) scores,cerebral blood flow reserve and related serum indexes homocysteine (Hcy),endothelin-1 (ET-1) and 8-iso-prostaglandin F_(2α)(8-iso-PGF_(2α))]before and after the treatment of two groups were compared.Result:The total effective rates of OSAHS treatment of observation group at first and second month after the treatment were significantly higher than those of control group (P<0.05),the sleep monitoring indexe and cognitive function related items of two groups before treatment were compared,the differences were not statistically significant (P>0.05),the sleep monitoring indexes and cognitive function related items of observation group at first and second month after the treatment were all significantly better than those of control group (P<0.05).Conclusion:The effect of noninvasive positive-pressure ventilation combined with routine treatment in patients with OSAHS complicated with mild cognitive impairment is better,and it can significantly improve the cognitive function of patients,so its application value in the patients with OSAHS complicated with mild cognitive impairment
作者
洪卫煌
张燮颖
麻益龙
HONG Weihuang;ZHANG Xieying;MA Yilong(Longyan People’s Hospital,Fujian Province,Longyan 364000,China;不详)
出处
《中国医学创新》
CAS
2022年第35期130-134,共5页
Medical Innovation of China
关键词
无创正压呼吸机
常规干预
阻塞性睡眠呼吸暂停低通气综合征
轻度认知障碍
认知功能
Noninvasive positive-pressure ventilation
Routine treatment
Obstructive sleep apneahypopnea syndrome
Mild cognitive impairment
Cognitive function
