摘要
肌球蛋白轻链激酶(MYLK)3基因是MYLK家族中的一员,主要在心肌组织中表达,其蛋白产物心脏特异性MYLK在心脏发育、心脏收缩和肌节组织的形成中起重要作用,当其表达降低或缺失时,可影响心肌形成及发育,导致先天性心脏病、心脏肥大、扩张型心脏病等多种心脏疾病。MYLK3基因的发现使临床从基因水平进一步了解心脏疾病,其可能为心脏疾病的诊断及治疗提供新的理论依据及治疗靶点。本文就MYLK3基因的结构、功能及其在心脏疾病中的研究进展作一综述。
Myosin light chain kinase(MYLK) 3 gene is a member of the MYLK family, which is mainly expressed in myocardial tissue. Its protein product, cardiac MYLK, plays an important role in cardiac development, cardiac contraction,and sarcomeric tissue formation. When its expression is reduced or absent, it can affect myocardial formation and development, leads to congenital heart disease, heart hypertrophy, dilated heart disease, and other heart diseases. The discovery of MYLK3 gene makes the clinical further understanding of heart diseases from the gene level, which may provide a new theoretical basis and therapeutic target for the diagnosis and treatment of heart diseases. This article reviews the structure and function of MYLK3 gene and its research progress in heart disease.
作者
曾婧
刘晓阳
白杨
王大维
ZENG Jing;LIU Xiaoyang;BAI Yang;WANG Dawei(Department of Oral and Maxillofacial Surgery,the Third Hospital of Hebei Medical University,Hebei Province,Shijiazhuang050051,China)
出处
《中国医药导报》
CAS
2022年第33期63-65,87,共4页
China Medical Herald
基金
河北省财政厅政府资助临床医学优秀人才培养项目。
