摘要
目的探讨硫酸镁联合硝苯地平在先兆早产患者中的应用效果。方法选取2019年5月至2021年1月联勤保障部队第九○○医院莆田医疗区收治的111例先兆早产患者作为研究对象,按照随机数字表法将其分为对照组(55例)和观察组(56例)。对照组患者在常规保胎治疗的基础上联合硫酸镁进行治疗,观察组患者在对照组基础上联合硝苯地平进行治疗。比较两组患者治疗后的血压、心率、延长孕龄时间、妊娠结局情况、不良反应情况、宫颈分泌物胎儿纤维连接蛋白(fFN)、胰岛素样生长因子结合蛋白-1(IGFBP-1)水平和血清C反应蛋白(CRP)水平变化情况。结果治疗前,两组患者的收缩压、舒张压、心率比较,差异无统计学意义(P>0.05);治疗8 h,两组患者的收缩压、舒张压均低于治疗前,心率快于治疗前,差异有统计学意义(P<0.05);观察组患者治疗3 d后宫颈分泌物fFN、IGFBP-1和血清CRP水平均低于对照组,差异有统计学意义(P<0.05)。观察组患者延长孕龄时间长于对照组,差异有统计学意义(P<0.05);观察组保胎有效率和成功率均高于对照组,差异有统计学意义(P<0.05);观察组新生儿窒息率低于对照组,差异有统计学意义(P<0.05);两组围生儿死亡率比较,差异无统计学意义(P>0.05);观察组患者的不良反应总发生率低于对照组,差异有统计学意义(P<0.05)。结论硫酸镁联合硝苯地平对先兆早产患者的保胎效果较单独使用硫酸镁的临床疗效更为理想,可改善宫颈分泌物fFN、IGFBP-1水平,减少不良妊娠结局,且不良反应少,安全性较高。值得在临床上推广应用。
Objective To investigate the application effect of magnesium sulfate combined with nifedipine in patients with threatened preterm labor.Methods A total of 111 patients with threatened preterm birth admitted to of the 900th Hospital of Joint Logistic Support Force Putian Medical District from May 2019 to January 2021 were selected as the research objects.According to the random number table method,they were divided into the control group(55 cases)and the observation group(56 cases).Patients in the control group were treated with Magnesium Sulfate on the basis of conventional fetal preservation treatment,and patients in the observation group were treated with Nifedipine on the basis of the control group.Blood pressure,heart rate,prolonged gestational age,pregnancy outcomes,adverse reactions,cervical secretions of fetal fibronectin(fFN),insulin-like growth factor binding protein-1(IGFBP-1)levels and serum C-reactive protein(CRP)levels were compared between the two groups after treatment.Results Before treatment,there were no significant differences in systolic blood pressure,diastolic blood pressure and heart rate between the two groups(P>0.05).At 8 h after treatment,the systolic blood pressure and diastolic blood pressure of the two groups were lower than those before treatment,and the heart rate was faster than that before treatment,and the differences were statistically significant(P<0.05).The levels of cervical secretions fFN,IGFBP-1 and serum CRP in the observation group after 3 days of treatment were lower than those in the control group,and the differences were statistically significant(P<0.05).The prolongation of gestational age in the observation group was longer than that in the control group,and the difference was statistically significant(P<0.05).The effective rate and success rate of fetal preservation in observation group were higher than those in control group,and the differences were statistically significant(P<0.05).The neonatal asphyxia rate in the observation group was lower than that in the contr
作者
林丽斌
LIN Libin(Department of Obstetrics and Gynecology,the 900^(th) Hospital of Joint Logistic Support Force Putian Medical District,Fujian Province,Putian 351100,China)
出处
《中国当代医药》
CAS
2022年第35期124-127,共4页
China Modern Medicine
关键词
宫缩抑制剂
硫酸镁
硝苯地平
胎儿纤维连接蛋白
Uterine contraction inhibitor
Magnesium Sulphate
Nifedipine
Fetal fibronectin
