摘要
目的:自制中药熏蒸包联合克霉唑给药治疗复发性念珠菌念珠菌阴道炎疗效及复发情况分析。方法:纳入2018年1月-2022年2月本院收治的复发性念珠菌阴道炎患者120例,随机分为观察组和对照组各60例,均给予克霉唑阴道片治疗,观察组同时应用自制中药熏包治疗,检测治疗前后免疫吸附法检测炎症因子水平,阴道菌群变化,双抗体夹心法检测热休克蛋白90(Hsp90)和烯醇化酶水平,观察两组疗效、临床症状评分、炎症因子、Hsp90、烯醇化酶、不良反应、阴道菌群、性生活质量、念珠菌阳性率和治疗3个月后复发率。结果:治疗后观察组总有效率(91.7%)高于对照组(61.7%),两组临床症状均降低且观察组低于对照组,两组炎症因子均下降且观察组低于对照组,观察组葡萄球菌、大肠杆菌和真菌菌群低于对照组,类杆菌和乳酸杆菌菌群高于对照组,两组Hsp90和烯醇化酶水平均下降且观察组低于对照组(均P<0.05);两组不良反应(8.3%、10.0%)无差异(P>0.05);治疗后,两组性生活质量评分均提升且观察组高于对照组(P<0.05);3个月后观察组念珠菌阳性率(7例,9.3%)和复发率(2例,2.7%)均低于对照组(18例,24.0%)(11例,14.7%)(均P<0.05)。结论:中药熏蒸联合克霉唑阴道给药治疗复发性念珠菌阴道炎,可显著提升临床疗效,改善患者症状和炎症因子水平,提升患者性生活质量、降低复发,且不增加不良反应。
Objective: To analyze the efficacy and recurrent situation of self-made traditional Chinese medicine fumigation bag combined with clotrimazole for treating patients with recurrent candidal vaginitis. Methods: A total of 120 patients with recurrent candida vaginitis were included in this study from January 2018 to February 2022. These patients were randomly divided into observation group and control group(60 cases in each group). The patients in the control group were treated with clotrimazole vaginal tablets, and the patients in the observation group were treated with clotrimazole vaginal tablets combined with self-made Chinese medicine fumigated bag. The levels of inflammatory factors and the changes of vaginal microflora before and after treatment of the patients in the two groups were detected by immunosorbent assay, and the levels of heat shock protein 90(Hsp90) and enolase of the patients in the two groups were detected by double-antibody sandwich assay. The efficacy, clinical symptom score, inflammatory factors level, Hsp90, enolase, adverse reactions, vaginal microflora, sex life quality, positive rate of candida, and recurrence rate after 3 months of treatment of the patients in the two groups were observed. Results: After treatment, the total effective rate(91.7%) of the patients in the observation group was significantly higher than that(61.7%) of the patients in the control group. The clinical symptoms of the patients in both groups had alleviated significantly, and degree of which of the patients in the observation group was significantly more than that of the patients in the control group. The inflammatory factors levels of the patients in both groups had decreased significantly, and which of the patients in the observation group were significantly lower than those of the patients in the control group.The counts of staphylococcus,escherichia coli,and fungal flora in vaginal of the patients in the observation group were significantly lower than those of the patients in the control group,but the counts
作者
郑静
张红转
朱春霞
全蕊
曾敏慧
ZHENG Jing;ZHANG Hongzhuan;ZHU Chunxia;QUAN Rui;ZENG Minhui(Jiashan Hospital of Traditional Chinese Medicine,Zhejiang Province,314000;Zigong Hospital of Traditional Chinese Medicine,Sichuan Province)
出处
《中国计划生育学杂志》
2022年第12期2733-2738,共6页
Chinese Journal of Family Planning
关键词
复发性念珠菌阴道炎
自制中药熏蒸包
克霉唑
临床症状
阴道菌群
复发
Recurrent candidalvaginitis
Self-made Chinese medicine fumigation bag
Clotrimazole
Clinical symptoms
Vaginal flora
Recurrence
