摘要
目的:了解江苏省基层妇幼保健机构对孕前优生健康检查项目常规化学三项丙氨酸氨基转移酶(ALT)、肌酐(Cr)、葡萄糖(GLU)的检测能力。方法:收集2013-2021年所有参评实验室ALT、Cr、GLU的室间质评结果,分析各项合格率、变异系数(CV)和结果符合率。结果:GLU、ALT的检测合格率分别稳定在94.0%、95.0%以上,Cr的合格率除2013年第1次外均稳定在96.0%以上。ALT、Cr、GLU的平均CV值均低于卫生计生委行业标准WS/T403-2012的室间质量评价标准。按方法学进行分组统计,Cr苦味酸法使用率逐年降低、酶法使用率逐年升高,苦味酸法CV值高于酶法、结果符合率低于酶法(P<0.05)。GLU氧化酶法使用率逐年降低、己糖激酶法的使用率逐年升高,己糖激酶法组和氧化酶法组CV值及结果符合率无统计学差异(P>0.05)。结论:2013-2021年江苏省基层妇幼保健机构孕前优生健康检查项目常规化学三项ALT、Cr、GLU的实验室检测能力、检测质量持续提高。Cr酶法检测质量明显优于苦味酸法,而氧化酶法与己糖激酶法的检测质量无明显差异。
Objective:To investigate the detection ability of alanine aminotransferase(ALT),creatinine(Cr),and glucose(GLU)in the pre-pregnancy health examination program of primary maternal and child health care institutions in Jiangsu Province.Methods:The returned results of ALT,Cr and GLU were collected from all participating laboratories from 2013 to 2021,and then the qualification rate,the coefficient of variation,and the result coincidence rate of each item were analyzed.Results:The qualification rates of GLU and ALT detection were stably over 94.0% and 95.0%,respectively.The qualification rate of Cr detection was stably over 96.0% except for the first test in 2013.The average CV values of ALT,Cr,and GLU detections were lower than those of the industry standard WS/T403-2012 of the National Health and Family Planning Commission.The utilization rate of Jaffe assay method for Cr detection had decreased year by year,while the utilization rate of enzymic method for Cr detection had increased year by year.The CV value of Jaffe assay method for Cr detection was significantly higher than that of enzymic method,and the result coincidence rate of Jaffe assay method was significantly lower than that of enzymic method(P<0.05).The utilization rate of oxidase method for GLU detection had decreased year by year,while the utilization rate of hexokinase method for GLU detection had increased year by year,and there were no significant differences in the CV value and the result coincidence rate between oxidase method and hexokinase method(P>0.05).Conclusion:From 2013 to 2021,the laboratory testing capacity and testing quality of ALT,Cr,and GLU in the pre-pregnancy health examination program of primary maternal and child Health institutions in Jiangsu Province were improved continuously.The detection quality of creatine oxidase method for Cr detection was significantly higher than that of Jaffe assay method,but there was no significant difference in the quality of GLU detection between oxidase method and hexokinase method.
作者
李孟兰
吴玉璘
封婕
刘帅妹
林宁
LI Menglan;WU Yulin;FENG Jie;LIU Shuaimei;LIN Ning(Jiangsu Health Development Research Center,NHC Contraceptives Adverse Reaction Surveillance Center,Nanjing,Jiangsu Province,210036)
出处
《中国计划生育学杂志》
2022年第12期2672-2676,共5页
Chinese Journal of Family Planning
关键词
实验室化学检测
丙氨酸氨基转移酶
肌酐
葡萄糖
室间质评
Laboratory chemical test
Alanine aminotransferase
Creatinine
Glucose
External quality assessment
