摘要
目的肝动脉化疗栓塞术(transcatheter arterial chemoembolization,TACE)结合抗病毒对乙肝病毒感染相关性肝癌患者应用价值分析。方法选取2018年1月—2020年12月盐城市第二人民医院收治的95例乙肝病毒感染相关性肝癌患者,以抽签法分为对照组(n=47)、观察组(n=48)。对照组采用TACE治疗,观察组采用TACE结合抗病毒治疗,对比两组治疗效果,乙肝病毒脱氧核糖核酸(HBV-DNA)、甲胎蛋白(AFP)水平,肝功能、免疫功能,预后情况。结果观察组总有效率显著高于对照组,差异有统计学意义(P<0.05);治疗前,两组HBV-DNA、AFP水平对比,差异无统计学意义(P>0.05);治疗后,观察组HBV-DNA、AFP水平优于对照组,差异有统计学意义(P<0.05);治疗前,两组肝功能、免疫功能水平对比,差异无统计学意义(P>0.05);治疗后,观察组肝功能、免疫功能水平优于对照组,差异有统计学意义(P<0.05);持续对患者随访1年,两组均无失防者,对照组1年生存率为80.85%(38/47),显著低于观察组的95.83%(46/48),差异有统计学意义(χ^(2)=5.206,P=0.022)。结论对乙肝病毒感染相关性肝癌患者,采用TACE结合抗病毒治疗效果显著,且可改善HBV-DNA、AFP、肝功能、免疫功能,预后良好。
Objective To analyze the application value of hepatic arterial chemoembolization(TACE)combined with antiviral therapy in patients with hepatitis B virus infection-related liver cancer.Methods A total of 95 patients with HBV infection-related liver cancer who were admitted to Yancheng Second People's Hospital from January 2018 to December 2020 were selected.They were divided into control group(n=47)and observation group(n=48)by drawing lots.The control group was treated with TACE,and the observation group was treated with TACE combined with antiviral therapy.The treatment effects,hepatitis B virus deoxyribonucleic acid(HBV-DNA),alpha-fetoprotein(AFP)levels,liver function,immune function,and prognosis were compared between the two groups.Results The total effective rate in the observation group was significantly higher than that in the control group,the difference was statistically significant(P<0.05).Before treatment,the levels of HBV-DNA and AFP in the two groups were compared,the difference was not statistically significant(P>0.05);after treatment,the levels of HBV-DNA and AFP in the observation group were better than the control group,the difference was statistically significant(P<0.05).Before treatment,the levels of liver function and immune function in the two groups were compared,the difference was not statistically significant(P>0.05);after treatment,the levels of liver function and immune function in the observation group were better than the control group,the difference was statistically significant(P<0.05).The patients were followed up for 1 year,and there were no failures in the two groups.The 1-year survival rate of the control group was 80.85%(38/47),which was significantly lower than 95.83%(46/48)of the observation group,the difference was statistically significant(χ^(2)=5.206,P=0.022).Conclusion For patients with HBV infection-related liver cancer,TACE combined with antiviral therapy has a significant effect,and can improve HBV-DNA,AFP,liver function,and immune function,and the prognosis is good.
作者
范庆秋
FAN Qingqiu(Department of Infectious Diseases,Yancheng Second People's Hospital,Yancheng,Jiangsu Province,224000 China)
出处
《世界复合医学》
2022年第10期106-109,共4页
World Journal of Complex Medicine
关键词
肝动脉化疗栓塞术
抗病毒
乙肝病毒
肝癌
预后情况
Hepatic arterial chemoembolization
Antiviral
Hepatitis B virus
Liver cancer
Prognosis
