摘要
目的探究还原型谷胱甘肽(GSH)联合抗病毒肝动脉化疗栓塞(TACE)治疗乙肝相关性肝癌的治疗效果。方法按随机数字表法将68例乙肝相关性肝癌患者分为观察组与对照组,每组34例。两组患者均行TACE联合抗病毒药物治疗,对照组患者给予常规保肝治疗,观察组在对照组基础上给予还原型谷胱甘肽治疗,观察两组患者临床疗效及不良反应,测定治疗前后患者丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、总胆红素(TBIL)、直接胆红素(DBIL)水平及血清中乙肝病毒(HBV-DNA)载量。结果观察组总有效率为97.06%,显著高于对照组(P<0.05);两组患者接受治疗后HBV-DNA载量均显著减少(P<0.05),观察组患者血清HBV-DNA载量显著低于对照组(P<0.05);治疗后两组患者ALT、AST、TBIL、DBIL水平均显著升高(P<0.05),观察组患者肝功能指标显著低于对照组,差异显著(P<0.05)。结论 GSH联合抗病毒TACE疗法能显著降低乙肝相关性肝癌患者的HBV-DNA载量,有效减轻肝功能损伤,效果显著。
Objective To explore the curative effect of reduced glutathione combined with antiviral transcatheter arterial chemoembolization（ TACE） in the treatment of hepatitis B associated liver cancer.Methods Sixty-eight patients with hepatitis B associated liver cancer were divided into the observation group and the control group by the random number table method,with 34 cases in each group. The two groups were treated with TACE combined with antiviral drugs. The control group was given conventional liver protection treatment,while the observation group was additionally treated with reduced glutathione. The clinical effect and adverse reactions in the two groups were observed. Levels of alanine aminotransferase（ ALT）,aspartate aminotransferase（ AST）,total bilirubin（ TBIL）,direct bilirubin（ DBIL） and serum hepatitis B virus（ HBV-DNA） load were determined before and after treatment. Results The total effective rate in the observation group was significantly higher than that in the control group（ P〈0.05）. The HBV-DNA load of the two groups decreased significantly after treatment（ P〈0.05）,especially in the observation group（ P〈0.05）. After treatment,levels of ALT,AST,TBIL and DBIL in the two groups increased significantly（ P〈0.05）,and the liver function indexes in the observation group were significantly lower than those in the control group（ P〈0.05）. Conclusion GSH combined with antiviral TACE can significantly reduce the HBV-DNA load in patients with hepatitis B associated liver cancer and effectively reduce liver function damage,with significant effect.
作者
宋燕
陈金华
易诗琼
杨楠
李德智
SONG Yan;CHEN Jinhua;YI Shiqiong;YANG Nan;LI Dezhi(Department of Oncology,Nanchong Central Hospital,Nanchong Sichuan 637000,Chin)
出处
《解放军预防医学杂志》
CAS
2018年第7期839-842,共4页
Journal of Preventive Medicine of Chinese People's Liberation Army
基金
四川省应用基础研究计划项目(No.2012JY0044)
关键词
还原型谷胱甘肽
抗病毒肝动脉化疗栓塞
乙肝相关性肝癌
reduced glutathione
antiviral transcatheter arterial chemoembolization
hepatitis B associated livercancer
