摘要
目的:观察肾毒宁方联合常规西药对慢性肾衰竭3~4期气虚血瘀证患者肾功能、炎性因子及中医证候积分的影响。方法:选取120例慢性肾衰竭3~4期气虚血瘀证患者,按随机数字表法分为观察组和对照组各60例。对照组予以常规西药治疗,观察组在对照组基础上加服肾毒宁方。比较2组中医证候积分、肾功能、免疫功能及炎症因子水平。结果:2组治疗后尿素氮(BUN)、肌酐(SCr)、尿酸(UA)较治疗前降低,内生肌酐清除率(CCr)较治疗前增高(P<0.05);观察组治疗后BUN、SCr、UA低于对照组,CCr高于对照组(P<0.05)。2组治疗后CD4^(+)、CD4^(+)/CD8^(+)较治疗前升高,CD8^(+)较治疗前降低(P<0.05);且观察组CD4^(+)、CD4^(+)/CD8^(+)高于对照组,CD8^(+)低于对照组(P<0.05)。治疗后,观察组免疫球蛋白(IgM、IgG、IgA)水平均高于对照组(P<0.05)。2组治疗后C-反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)水平较治疗前降低(P<0.05),且观察组降低程度高于对照组(P<0.05)。结论:肾毒宁方联合常规西药可有效改善慢性肾衰竭3~4期气虚血瘀证患者肾功能和临床症状,提高免疫力,降低炎症反应。
Objective:To observe the effect of Shenduning Prescription combined with conventional western medicine on the kidney function,inflammatory factors and Chinese medicine syndrome scores in patients with stage 3-4 chronic renal failure with qi deficiency and blood stasis syndrome.Methods:A total of 120 patients with stage 3-4 chronic renal failure with qi deficiency and blood stasis syndrome were selected and divided into the observation group and the control group according to the random number table method,with 60 cases in each group.The control group was treated with conventional western medicine,and the observation group was treated with Shenduning Prescription based on the treatment of the control group.The Chinese medicine syndrome scores,kidney function,immune function and levels of inflammatory factors were compared between the two groups.Results:After treatment,the levels of blood urea nitrogen(BUN),serum creatinine(SCr)and uric acid(UA)were decreased,and the endogenous creatinine clearance rates(CCr)were increased in the two groups(P<0.05).After treatment,the levels of BUN,SCr and UA in the observation group were lower and the CCr was higher than those in the control group(P<0.05).After treatment,the levels of CD4^(+) and CD4^(+)/CD8^(+) in the two groups were increased when compared with those before treatment,and the levels of CD8^(+) were decreased(P<0.05);the levels of CD4^(+) and CD4^(+)/CD8^(+) in the observation group were higher and the CD8^(+) level was lower than those in the control group(P<0.05).After treatment,the levels of immunoglobulin(IgM,IgG,IgA)in the observation group were higher than those in the control group(P<0.05).The levels of C-reactive protein(CRP),tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)in the two groups after treatment were decreased when compared with those before treatment(P<0.05),and the degree of reduction in the observation group was higher than that in the control group(P<0.05).Conclusion:The therapy of Shenduning Prescription combined with conventional we
作者
周华虹
董艺
成栋
傅晓骏
ZHOU Huahong;DONG Yi;CHENG Dong;FU Xiaojun
出处
《新中医》
CAS
2022年第21期101-104,共4页
New Chinese Medicine
基金
浙江省中医药科技计划项目(2021ZB314)。
关键词
慢性肾衰竭
肾毒宁方
肾功能
炎症因子
中医证候积分
Chronic renal failure
Shenduning Prescription
Kidney function
Inflammatory factor
Chinese medicine syndrome score
