摘要
目的探讨乙型肝炎病毒(HBV)核酸检测(NAT)反应性献血者可行性归队方案。方法分析2015年1月至2020年12月在韶关市中心血站无偿献血中HBV NAT反应性且酶联免疫吸附试验(ELISA)无反应性的献血者。召回63例进入归队流程,分别于第3、6个月时进行追踪随访检测,采用ELISA与病毒NAT复检反应性项目,统计2次复检结果合格率情况,评估献血者归队献血资格,分析HBV NAT反应性献血者可行性归队方案。结果2015—2020年献血人数共146319例,共召回63例归队复查;63例HBV NAT反应性献血者第1次追踪检测结果ELISA筛查反应性1例,占1.59%;NAT筛查反应性9例,占14.29%;53例ELISA无反应性/HBV DNA无反应性献血者第2次追踪检测结果ELISA筛查反应性为0例,NAT筛查反应性为5例,占9.43%;经2次追踪复查结果显示,有76.19%(48/63)的献血者ELISA无反应性/HBV DNA无反应性,符合归队献血资格。结论HBV NAT反应性献血者中存在假反应性结果,也存在感染康复期群体,开展献血归队方案可为献血者归队的科学管理程序提供依据,有利于减少血源流失。
Objective To explore the feasible scheme of reentry of blood donors with reactive results of hepatitis B virus(HBV)nucleic acid testing(NAT).Methods The blood donors who were reactive to HBV NAT but non-reactive to enzyme-linked immunosorbent assay(ELISA)participating in voluntary blood donation in Central Blood Station of Shaoguan City from January 2015 to December 2020 were analyzed,and 63 participants were recalled into the reentry process and followed up at Month 3 and Month 6,respectively.The ELISA and HBV NAT items were performed for reactivity re-examination.The qualification rates of the re-examination results were counted twice,the reentry eligibility of blood donors was evaluated,and the feasible scheme of reentry of HBV NAT reactive blood donors was analyzed.Results Of the 146319 people who participated in blood donation from 2015 to 2020,63 were recalled for re-examination for reentry.During the first follow-up testing among 63 HBV NAT reactive blood donors,1 participant was reactive in ELISA screening,accounting for 1.59%;9 participants were reactive in NAT screening,accounting for 14.29%.During the second followup testing among 53 ELISA non-reactive/HBV DNA non-reactive blood donors,no participant was reactive in ELISA screening,and 5 participants were reactive in NAT screening,accounting for 9.43%.The results of the two follow-up examinations showed that 76.19%(48/63)of the donors were ELISA non-reactive/HBV DNA non-reactive,who were qualified for reentry.Conclusion Since there are false reactive results among HBV NAT reactive blood donors and convalescent population,the implementation of donor reentry scheme can provide basis for scientific management procedure of donor reen try and help to reduce loss of blood resources.
作者
刘智敏
霍宝锋
王莉娟
梁海燕
林奕斌
何辉
张天弼
LIU Zhimin;HUO Baofeng;WANG Lijuan;LIANG Haiyan;LIN Yibin;HE Hui;ZHANG Tianbi(Department of Clinical Laboratory,Central Blood Station of Shaoguan City,Guangdong,Shaoguan 512026,China)
出处
《中国医药科学》
2022年第22期169-172,共4页
China Medicine And Pharmacy
基金
广东省韶关市科技计划(社会发展方向)项目(210803154532789)。
关键词
乙型肝炎病毒
核酸检测
献血者
归队
血源
Hepatitis B virus
Nucleic acid testing
Blood donor
Reentry
Blood resources
