摘要
Trop2基因在多种恶性肿瘤的发生、发展中起重要作用。三阴性乳腺癌(triple-negative breast cancer,TNBC)的滋养层细胞表面抗原2(trophoblast cell-surface antigen 2, Trop2)基因能调控周期蛋白D1(cyclin D1)及上皮钙黏素的表达,进而促进TNBC转移及侵袭。本文对Trop2基因的结构、功能、作用机制及在TNBC中的表达和治疗进行综述,以期找到TNBC的治疗靶点,探索新疗法。
Trophoblast cell-surface antigen 2(Trop2) gene plays an important role in the development of various malignant tumors. Trop2 gene regulates the expression of cyclin D1 and E-cadherin in triple-negative breast cancer(TNBC),and promote the metastasis and invasion of TNBC. In this study, the structure, function, mechanism of action, the expression of Trop2 gene and treatment of TNBC were reviewed to find therapeutic targets for TNBC and explore new therapy.
作者
王杰强(综述)
马德奎(审校)
WANG Jieqiang;MA Dekui(Breast Center,Zhaoqing First People's Hospital affiliated to Guangdong Medical University,Guangdong Zhanjiang 524000,China)
出处
《外科理论与实践》
2022年第5期473-477,共5页
Journal of Surgery Concepts & Practice
