摘要
目的探讨结肠癌组织中人滋养层细胞表面抗原2(TROP-2)蛋白表达及临床意义。方法收集2017年3月至2018年12月行手术切除并经病理组织学确诊的结肠癌组织及相应的癌旁组织85例,采用免疫组化染色法检测组织TROP-2蛋白表达;分析其表达与结肠癌临床病理特征的关系。采用Logistic回归模型分析影响术后复发转移的因素。结果结肠癌组织中TROP-2蛋白阳性表达率为67.06%(57/85),高于癌旁正常组织的24.71%(21/85),差异有统计学意义(P<0.001);其表达与肿瘤直径、病灶位置、Dukes分期、淋巴结转移、远处转移有关(P<0.05)。39例Dukes'B+C期患者发生术后复发转移,复发转移组TROP-2蛋白阳性表达率高于未复发转移组[79.49%(31/39)vs.39.39%(13/33)],差异具有统计学意义(P<0.001)。Logistic回归模型分析,TROP-2蛋白阳性表达(HR=5.633,95%CI:2.886~9.161)是术后复发转移的独立危险因素(P<0.05)。结论TROP-2蛋白在结肠癌组织中高表达,也是结肠癌患者术后复发转移的独立危险因素。
Objective To investigate the expression of trophoblast cell surface antigen 2(TROP-2)protein in colon cancer tissue and its clinical significance.Methods A total of 85 cases of colon cancer tissues and corresponding paracancerous tissues that were surgically resected and pathologically diagnosed from March 2017 to December 2018 were collected,and the expression of TROP-2 protein in the tissues was detected by immunohistochemical staining.The relationship with clinicopathological features of colon cancer was analyzed.Logistic regression model was used to analyze the factors affecting postoperative recurrence and metastasis.Results The positive expression rate of TROP-2 protein in colon cancer tissues was 67.06%(57/85),significantly higher than that in adjacent normal tissues(24.71%,21/85),and the difference was statistically significant(P<0.001).Its expression was correlated with tumor diameter,lesion location,Dukes stage,lymph node metastasis and distant metastasis(P<0.05).Thirty-nine Dukes'B+C stage patients had postoperative recurrence and metastasis,and the positive expression rate of TROP-2 protein in the recurrence and metastasis group was higher than that in the non-recurrence and metastasis group[79.49%(31/39)vs.39.39%(13/33)],with statistical significance(P<0.001).Logistic regression model showed that positive expression of TROP-2 protein(HR=5.633,95%CI:2.886-9.161)was an independent risk factor for postoperative recurrence and metastasis(P<0.05).Conclusion TROP-2 protein is highly expressed in colon cancer tissues and is an independent risk factor for postoperative recurrence and metastasis of colon cancer patients.
作者
罗超元
黄南祺
吴小兵
刘文明
李志发
LUO Chaoyuan;HUANG Nanqi;WU Xiaobing;LIU Wenming;LI Zhifa(Department of Gastrointestinal Surgery, the Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, China)
出处
《临床肿瘤学杂志》
CAS
2021年第2期159-162,共4页
Chinese Clinical Oncology
关键词
结肠癌
人滋养层细胞表面抗原2
术后复发转移
危险因素
Colon carcinoma
Human trophoblast cell surface antigen 2(TROP-2)
Postoperative recurrence and metastasis
Risk factor
