摘要
目的探讨结直肠癌围化疗期颊针防治奥沙利铂神经毒性及胃肠道反应的的临床疗效。方法选取接受XELOX方案治疗的Ⅱ/Ⅲ期结直肠癌根治术后患者60例。按随机分组法分为对照组、低频颊针组、高频颊针组,每组20例。对照组给予XELOX方案+甲钴胺,低频颊针组在对照组基础上联合低频颊针治疗,高频颊针组在对照组基础上联合高频颊针治疗。记录3组患者化疗后的神经毒性和胃肠道反应。结果高频颊针组化疗后神经毒性的发生率、严重程度均低于对照组,差异有统计学意义(P<0.05);低频颊针组恶心呕吐的发生率、严重程度均低于对照组,差异有统计学意义(P<0.05)。结论高频颊针能预防及降低奥沙利铂所产生的神经损伤毒副作用,低频颊针能预防及降低奥沙利铂的胃肠道毒副反应,改善患者的生活质量,提高治疗依从性,可在临床治疗中推广使用。
Objective To investigate the clinical effect of buccal acupuncture on the neurotoxicity of oxaliplatinand gastrointestinal reaction during perichemotherapy for colorectal cancer.Methods Sixty patients with StageⅡ/Ⅲcolorectal cancer,who received XELOX regimen in hospital after radical resection,were selected.According to the random grouping method,they were divided into 3 groups,control group,low-frequency buccal acupuncture treatment group and high-frequency buccal acupuncture treatment group(n=20).The control group was given with XELOX regimen plus mecobalamine;the low-frequency buccal acupuncture group was given with combined low-frequency buccal acupuncture on the basis of the control group;and the high-frequency buccal acupuncture group was given with high-frequency buccal acupuncture on the basis of the control group.The incidence and severity of neurotoxicity and gastrointestinal reaction after chemotherapy were recorded in the 3 groups.Results The incidence and severity of neurotoxicity after chemotherapy in high-frequency buccal acupuncture group were significantly lower than those in control group(P<0.05).The incidence and severity of nausea and vomiting in low-frequency buccal acupuncture group were significantly lower than those in control group(P<0.05).Conclusion High-frequency buccal acupuncture can prevent and reduce the toxic and side effects of oxaliplatin on nerve injury.Low-frequency buccal acupuncture can prevent and reduce gastrointestinal reactions caused by oxaliplatin.
作者
张汉文
吴依芬
李浩
叶兆康
樊秀
王刚
ZHANG Han-wen;WU Yi-fen;LI Hao;YE Zhao-kang;FAN Xiu;WANG Gang(Department of Oncology DivisionⅣ,Affiliated Dongguan Hospital of Southern Medical University(Dongguan People’s Hospital),Dongguan 523000,Guangdong,China;不详)
出处
《广东医学》
CAS
2022年第9期1141-1144,共4页
Guangdong Medical Journal
基金
国家自然科学基金青年项目(81803877)
广东省中医药局科研项目(20202220)
东莞市社会科技发展(重点)项目(202050715001207)。
关键词
结直肠癌
颊针
奥沙利铂
神经毒性
胃肠道反应
colorectal cancer
buccal acupuncture
oxaliplatin
neurotoxicity
gastrointestinal reaction
