摘要
目的探究药师参与的用药管理模式对新生儿抗生素使用合理性的影响。方法选取绍兴市妇幼保健院2019年1~3月住院的127例新生儿为对照组,2019年4~6月住院的131例新生儿为观察组。对照组患儿根据风险评估策略使用抗生素,观察组患儿在对照组的基础上接受临床药师干预,比较两组患儿的抗生素使用情况、病原学检测率、药物不合理应用情况、抗生素相关不良反应发生情况和治疗结局。结果观察组患儿的抗生素使用率低于对照组,抗生素使用天数短于对照组,病原学检测率高于对照组(P<0.05);观察组患儿的剂量不合理、给药方式不当、给药时间不合理和药物种类选择不合理等药物不合理应用情况发生率均低于对照组(P<0.05);观察组患儿的抗生素相关不良反应总发生率低于对照组(P<0.05);随访结果显示,观察组患儿的住院时间明显短于对照组,再入院率低于对照组(P<0.05),两组患儿的病死率比较差异无统计学意义(P>0.05)。结论对新生儿实施药师参与的用药管理模式,可明显改善患儿的抗生素使用情况,提高病原学检测率,减少药物不合理应用情况与不良反应,缩短住院时间,降低再入院率。
Objective To explore the effect of medication management with pharmacists’participation on the rationality of antibiotics use in neonates.Methods A total of 127 neonates hospitalized from January to March 2019 in Shaoxing Maternal and Child Health Hospital were selected as control group,and 131 neonates hospitalized from April to June 2019 were selected as observation group.Neonates in control group were treated with antibiotics according to the risk assessment strategy,and those in observation group received clinical pharmacist intervention on this basis.Antibiotics use,etiological detection rate,unreasonable drugs use,antibiotics-related adverse reactions and treatment outcomes were compared between the two groups.Results The antibiotics use rate in observation group was lower than that in control group,duration of antibiotics use was shorter than that in control group,and etiological detection rate was higher than that in control group(P<0.05).The incidence of irrational drugs use such as unreasonable dose,improper administration method,unreasonable administration time and unreasonable choice of drug types in observation group was lower than that in control group(P<0.05).The total incidence of antibiotic-related adverse reactions in observation group was lower than that in control group(P<0.05).The follow-up results showed that the hospital stay of observation group was significantly shorter than that of control group,and readmission rate was lower than that in control group(P<0.05).There was no significant difference in the mortality between the two groups(P>0.05).Conclusion Medication management with pharmacists’participation can significantly improve antibiotics use,increase etiological detection rate,reduce unreasonable drugs use and adverse reactions,shorten hospital stay and decrease readmission rate in neonates.
作者
徐潇
章铭
冯城
XU Xiao;ZHANG Ming;FENG Cheng(Department of Pharmacy,Shaoxing Maternal and Child Health Hospital,Zhejiang,Shaoxing 312000,China)
出处
《中国现代医生》
2022年第34期83-86,共4页
China Modern Doctor
关键词
抗生素
新生儿
合理用药
临床药师
Antibiotic
Neonate
Rational medication
Clinical pharmacist
