摘要
人体内肠道菌群数量巨大,功能复杂,影响宿主免疫系统、骨代谢、脂代谢、微循环等多个方面,目前借助16S rRNA基因扩增子测序和基于气相色谱-质谱代谢组学分析,初步认识肠道菌群致病机制,并使用有益菌干预疾病,效果明显。本文就可能与非创伤性股骨头坏死相关的肠道菌群研究进行梳理,为本病防治提供新思路。
The number of intestinal flora in human body is huge and its function is complex,which affects the host immune system,bone metabolism,lipid metabolism,microcirculation and other aspects.At present,with the help of 16S rRNA gene amplicon sequencing and metabolomics analysis based on gas chromatography-mass spectrometry,people preliminarily understand the pathogenic mechanism of intestinal flora,and used beneficial bacteria to intervene the disease,which has obvious effect.This article combed the research on intestinal flora that may be related to non-traumatic osteonecrosis of femoral head,so as to provide new ideas for the prevention and treatment of this disease.
作者
肖振
李盛华
周明旺
王晓萍
吉星
杨波
XIAO Zhen;LI Shenghua;ZHOU Mingwang;WANG Xiaoping;JI Xing;YAO Bo(Gansu University of Chinese Medicine,Lanzhou 730000,China;Gansu Hospital of Traditional Chinese Medicine,Lanzhou 730050,China)
出处
《中国中医药信息杂志》
CAS
CSCD
2022年第12期151-151,152-156,共6页
Chinese Journal of Information on Traditional Chinese Medicine
基金
国家自然科学基金(81860861)。
关键词
肠道菌群
非创伤性股骨头坏死
代谢组学
综述
intestinal flora
non-traumatic osteonecrosis of femoral head
metabonomics
review
