摘要
本文主要研究不同剂型氟苯尼考在日本鳗鲡上的药物消除规律,在25℃下,按30 mg/kg(以氟苯尼考计)剂量,多次口灌给药后于不同时间取日本鳗鲡血浆、肝脏、肾脏、肌肉等样品进行HPLC检测,得出氟苯尼考溶液和氟苯尼考粉在日本鳗鲡血浆、肝脏、肾脏、肌肉中半衰期分别为8.9 d、6.4 d、11.2 d、5.7 d和8.3 d、6.9 d、7.5 d、8.2 d,最高残留量如规定为0.2μg/g,最大休药期分别为32.1 d和18.2 d,以此为临床使用确定不同氟苯尼考制剂休药期提供依据。
This paper mainly studies the drug elimination law of different dosage forms of florfenicol on Japanese eel.At 25℃,at the dose of 30 mg/kg(calculated by florfenicol),after oral administration for many times,samples of Japanese eel plasma,liver,kidney,and muscle were taken at different times for HPLC detection,and the results showed that florfenicol solution and florfenicol powder the half-life in Japanese eel plasma,liver,kidney and muscle is 8.9,6.4,11.2,5.7 days and 8.3,6.9,7.5,8.2 days respectively,and the maximum residue is 0.2μg/g as specified,the maximum drug withdrawal period is 32.1 days and 18.2 days respectively,which provides a basis for determining the withdrawal period of different florfenicol preparations for clinical use.
作者
李惠静
李忠琴
庄若飞
林章秀
罗琳
李莉
Li Huijing;Li Zhongqin;Zhuang Ruofei;Lin Zhangxiu;Luo Lin;Li Li(Xiamen Huiying Animal Pharmaceutical Co.Ltd.,Fujian Xiamen 361023;Engineering Research Center of the Modern Technology for Eel Industry,Ministry of Education,Fujian Xiamen 361021;Fisheries College of Jimei University,Fujian Xiamen 361021)
出处
《福建畜牧兽医》
2022年第6期7-12,共6页
Fujian Journal of Animal Husbandry and Veterinary medicine
基金
国家重点研发计划(2020YFD0900102)
鳗鲡现代产业技术教育部工程研究中心开放基金(RE202106)
国家现代农业产业技术体系(CARS-46)
福建省科技计划项目(2021N0014)资助。
关键词
氟苯尼考粉
氟苯尼考溶液
日本鳗鲡
消除规律
Florfenicol powder
Florfenicol solution
Anguilla Japonica
Elimination rule
