摘要
川崎病是一种累及冠状动脉的急性全身性血管炎,是儿童获得性心脏病的主要原因。目前川崎病的病因仍不明确,但国内外普遍认为,川崎病是一种由感染和遗传易感因素共同作用引起的炎症级联反应。调节性T细胞通常指CD4^(+)CD25^(+)Foxp3^(+)T细胞,是一种具有炎症抑制功能的T细胞。调节性T细胞和川崎病的病理生理、治疗和预后存在一定的相关性。调节性T细胞功能障碍可能参与了川崎病的致病机制,但是目前相关的研究较少。该文就近些年调节性T细胞在川崎病中的研究进展进行综述,总结了调节性T细胞参与川崎病发生和修复的作用机制,对靶向调节性T细胞治疗在川崎病预防冠脉损伤的研究前景进行展望。
Kawasaki disease is an acute,systemic vasculitis that easily injures coronary arteries and is the leading cause of acquired heart disease in children.Although the cause of Kawasaki disease remains unknown,it is widely believed that the pathogenesis of Kawasaki disease is an inflammatory cascade caused by a combination of infection and genetic predisposition.Regulatory T cells,which express Foxp3^(+),CD4^(+)and CD25^(+),are a T-cell subpopulation specialized in immune suppression.There are some correlations between regulatory T cells and Kawasaki disease in pathophysiology,treatment and prognosis.The dysfunction of regulatory T cells may be involved with the pathogenesis of Kawasaki disease,but there are few researches on it.This article reviews the progress of regulatory T cells in Kawasaki disease in recent years and summarizes the mechanism of regulatory T cells in the occurrence and repair of Kawasaki disease,prospecting the research future of targeted regulatory T cells therapy in the prevention of coronary artery lesions in Kawasaki disease.
作者
许佳雯(综述)
王毓佳
龚方戚(审校)
Xu Jiawen;Wang Yujia;Gong Fangqi(Department of Cardiology,the Children′s Hospital,Zhejiang University School of Medicine,Hangzhou 310052,China)
出处
《国际儿科学杂志》
2022年第10期663-667,共5页
International Journal of Pediatrics
基金
国家自然科学基金(81970434)。
关键词
调节性T细胞
川崎病
免疫抑制
Regulatory T cells
Kawasaki disease
Immunosuppression
