摘要
采用网状Meta分析比较不同中药注射液联合常规治疗对卒中相关性肺炎的疗效和安全性.基于中国知网(CNKI)、万方(Wanfang)、维普(VIP)、PubMed、Web of Science、Cochrane Library数据库,检索自建库至2022年4月1日,筛选可纳入文献,采用Stata 17软件进行数据分析.共筛选出文献1189篇,最终纳入72项研究,5819例患者,涉及6种中药注射液(痰热清注射液、醒脑净注射液、血必净注射液、喜炎平注射液、参附注射液、参麦注射液).网状Meta分析疗效排序结果显示:①在改善临床总有效率方面,累计概率排名曲线下面积(SUCRA)排序为喜炎平注射液+常规治疗>血必净注射液+常规治疗>痰热清注射液+常规治疗>参麦注射液+常规治疗>醒脑净注射液+常规治疗>参附注射液+常规治疗>常规治疗;②在改善美国国立卫生研究院卒中量表(NIHSS)评分方面,SUCRA排序为血必净注射液+常规治疗>醒脑净注射液+常规治疗>痰热清注射液+常规治疗>参附注射液+常规治疗>常规治疗;③在缩短平均退热时间方面,SUCRA排序为喜炎平注射液+常规治疗>痰热清注射液+常规治疗>血必净注射液+常规治疗>常规治疗;④在缩短平均住院时间方面,SUCRA排序为喜炎平注射液+常规治疗>血必净注射液+常规治疗>痰热清注射液+常规治疗>参麦注射液+常规治疗>常规治疗.结果表明,常规治疗联合使用痰热清注射液、血必净注射液、喜炎平注射液、醒脑净注射液、参麦注射液、参附注射液的临床疗效均优于单独使用常规治疗.但由于不同干预措施纳入研究质量和方法学的局限性,该结论仍需开展更多高质量、设计严谨的随机对照试验(RCT)进一步验证.
Network Meta-analysis was conducted to compare the efficacy and safety of different Chinese medicine injections combined with conventional therapy in the treatment of stroke-associated pneumonia.CNKI,Wanfang,VIP,PubMed,Web of Science,and Cochrane Library were searched for the relevant literature pubslished from inception to April 1,2022.Stata 17 was used for data analysis.After screening of 1189 papers,72 studies were finally selected,which involved 5819 patients and 6 Chinese medicine injections(Tanreqing Injection,Xingnaojing Injection,Xuebijing Injection,Xiyanping Injection,Shenfu Injection,and Shenmai Injection).The network Meta-analysis ranked the injections as follows.①In terms of improving the total clinical effective rate,the surface under the cumulative ranking curve(SUCRA)followed the order of Xiyanping Injection+conventional therapy>Xuebijing Injection+conventional therapy>Tanreqing Injection+conventional therapy>Shenmai Injection+conventional therapy>Xingnaojing Injection+conventional therapy>Shenfu Injection+conventional therapy>conventional therapy.②In terms of recovering the National Institute of Health stroke scale(NIHSS)scores,the SUCRA followed the order of Xuebijing Injection+conventional therapy>Xingnaojing Injection+conventional therapy>Tanreqing Injection+conventional therapy>Shenfu Injection+conventional therapy>conventional therapy.③In reducing the average time to abatement of fever,the SUCRA followed the order of Xiyanping Injection+conventional therapy>Tanreqing Injection+conventional therapy>Xuebijing Injection+conventional therapy>conventional therapy.④In terms of reducing the mean hospital stay,the SUCRA followed the order of Xiyanping Injection+conventional therapy>Xubijing Injection+conventional therapy>Tanreqing Injection+conventional therapy>Shenmai Injection+conventional therapy>conventional therapy.The clinical efficacy of Tanreqing Injection,Xuebijing Injection,Xiyanping Injection,Xingnaojing Injection,Shenmai Injection,or Shenfu Injection combined with conventional the
作者
姬文帅
张康
王艺浩
关胜男
王海峰
JI Wenshuai;ZHANG Kang;WANG Yi-hao;GUAN Sheng-nan;WANG Hai-feng(Henan University of Chinese Medicine,Zhengzhou 450000,China;the First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000,China;Co-construction Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan&Education Ministry of China,Zhengzhou 450000,China)
出处
《中国中药杂志》
CAS
CSCD
北大核心
2022年第19期5353-5364,共12页
China Journal of Chinese Materia Medica
基金
国家自然科学基金项目(81774222,82074411)
河南省中医药科学研究重大专项(20-21ZYZD04)
河南省中医药科学研究专项(拔尖人才)(2019ZYBJ05)
河南省高校科技创新团队支持计划项目(22IRTSTHN029)。
关键词
卒中相关性肺炎
中药注射液
网状Meta分析
stroke-associated pneumonia
Chinese medicine injection
network Meta-analysis
