摘要
系统评价不同中药注射液联合常规西药治疗稳定型心绞痛的疗效及安全性。计算机检索PubMed、Cochrane Library、EMbase、Web of Science、中国知网(CNKI)、万方(Wanfang)、维普(VIP)、中国生物医学文献服务系统(SinoMed),搜集中药注射液联合常规西药治疗稳定型心绞痛的随机对照试验(RCT),检索时限均为建库至2022年7月8日,由2名研究者独立筛选文献、提取资料、评价纳入研究的偏倚风险后,采用Stata 15.1软件进行网状Meta分析。共纳入52项RCTs,包括4828例患者、9种中药注射液(丹红注射液、丹参多酚酸盐注射液、丹参酮ⅡA磺酸钠注射液、丹参川芎嗪注射液、大株红景天注射液、葛根素注射液、红花黄色素注射液、参麦注射液、血塞通注射液)。网状Meta分析疗效排序结果显示:(1)提高心绞痛疗效方面,累计概率排名曲线下面积(SUCRA)排序为常规西药联合丹参川芎嗪注射液>联合丹参酮ⅡA磺酸钠注射液>联合丹红注射液>联合丹参多酚酸盐注射液>联合血塞通注射液>联合参麦注射液>联合葛根素注射液>联合红花黄色素注射液>联合大株红景天注射液;(2)提高心电图疗效方面,SUCRA排序为常规西药联合丹参川芎嗪注射液>联合葛根素注射液>联合丹红注射液>联合丹参多酚酸盐注射液>联合参麦注射液>联合血塞通注射液>联合红花黄色素注射液>联合丹参酮ⅡA磺酸钠注射液>联合大株红景天注射液;(3)升高高密度脂蛋白胆固醇(HDL-C)方面,SUCRA排序为常规西药联合丹红注射液>联合参麦注射液>联合红花黄色素注射液>联合血塞通注射液>联合丹参酮ⅡA磺酸钠注射液>联合大株红景天注射液;(4)降低低密度脂蛋白胆固醇(LDL-C)方面,SUCRA排序为常规西药联合红花黄色素注射液>联合丹红注射液>联合参麦注射液>联合丹参酮ⅡA磺酸钠注射液>联合大株红景天注射液>联合血塞通注射液;(5)安全性方面,中药注�
This study aimed to systematically evaluate the efficacy and safety of different Chinese medicine injections combined with conventional western medicine for stable angina pectoris.PubMed,Cochrane Library,EMbase,Web of Science,CNKI,Wanfang,VIP,and SinoMed were searched to collect randomized controlled trial(RCT)of Chinese medicine injection combined with conventio-nal western medicine in the treatment of stable angina pectoris from the inception of the databases to July 8,2022.Two researchers independently screened the literature,extracted the data,and evaluated the risk of bias of the included studies.Stata 15.1 was used for network Meta-analysis.A total of 52 RCTs were included,involving 4828 patients treated by 9 Chinese medicine injections(Danhong Injection,Salvia Miltiorrhiza Polyphenol Hydrochloride Injection,Tanshinone SodiumⅡASulfonate Injection,Salvia Miltiorrhiza Ligustrazine Injection,Dazhu Hongjingtian Injection,Puerarin Injection,Safflower Yellow Pigment Injection,Shenmai Injection and Xuesaitong Injection).The network Meta-analysis showed that:(1)in terms of improving the efficacy of angina pectoris,the surface under the cumulative ranking curve(SUCRA)followed the order of conventional western medicine combined with Salvia Miltiorrhiza Ligustrazine Injection>Tanshinone SodiumⅡASulfonate Injection>Danhong Injection>Salvia Miltiorrhiza Polyphenol Hydrochloride Injection>Xuesaitong Injection>Shenmai Injection>Puerarin Injection>Safflower Yellow Pigment Injection>Dazhu Hongjingtian Injection;(2)in terms of improving the efficacy of electrocardiogram(ECG),SUCRA followed the order of conventional western medicine combined with Salvia Miltiorrhiza Ligustrazine Injection>Puerarin Injection>Danhong Injection>Salvia Miltiorrhiza Polyphenol Hydrochloride Injection>Shenmai Injection>Xuesaitong Injection>Safflower Yellow Pigment Injection>Tanshinone SodiumⅡASulfonate Injection>Dazhu Hongjingtian Injection;(3)in terms of increasing high-density lipoprotein cholesterol(HDL-C),SUCRA followed the order of conve
作者
王薇
曹璐
任鹏
朱贝贝
刘凯
WANG Wei;CAO Lu;REN Peng;ZHU Bei-bei;LIU Kai(Gansu University of Chinese Medicine,Lanzhou 73000,China;Evidence-based Medicine Center of Gansu University of Chinese Medicine,Lanzhou 730000,China)
出处
《中国中药杂志》
CAS
CSCD
北大核心
2023年第6期1652-1663,共12页
China Journal of Chinese Materia Medica
基金
甘肃省“双一流”科研重点项目(GSSYLXM-05)
甘肃中医药大学2022年研究生创新基金项目(2022CX47)。
关键词
稳定型心绞痛
中药注射液
网状Meta分析
临床疗效
stable angina pectoris
Chinese medicine injection
network Meta-analysis
clinical curative effect
