摘要
骨缺损越来越威胁着人类的健康,其临床发病率逐年增加,常常与感染并存,治疗非常困难且难以奏效,因此,针对感染性骨缺损的研究越来越多,目前针对感染性骨缺损的治疗方法主要为抗生素骨水泥钢珠。随着新型支架材料的不断发明,3D打印的支架材料结合抗菌因子材料逐渐应用于临床,为感染性骨缺损患者带来了喜讯,特别是可生物吸收的具备抗菌活性的支架材料,能满足各种临床骨缺损形状对临床越来越需要,但该材料仍处于研发阶段,还需要更多的实验来进一步研究和开发,使之更贴合临床实际应用,为感染性骨缺损提供新的治疗方案。
Bone defects are increasingly threatening the human health,its morbidity in clinic is increasing year by year,which often coexists with infection.Its treatment is very difficult and is difficult to be effective.Therefore,there are more and more researches on infectious bone defects.At present,the main treatment method for infectious bone defects is antibiotic bone cement steel balls.With the invention of new scaffold materials,3D printed scaffold materials combined with antibacterial factor materials have been gradually applied in clinical practice,bringing good news to the patients with infectious bone defects,especially biological absorbed scaffold material with antibacterial activity can meet the increasing clinical needs of various clinical bone defect shapes,but the material is still in the research and development stage,and more experimental researches are needed for further research and development so as to make it more suitable for clinical practical application and provide a new treatment scheme for the treatment of infectious bone defects.
作者
冯建波
程飘涛
李陈诚
宫首航(综述)
彭笳宸(审校)
FENG Jianbo;CHENG Piaotao;LI Chencheng;GONG Shouhang;PENG Jiachen(Department of Joint Surgery,Zheng'an County People's Hospital,Zunyi,Guizhou 563400,China;Department of Joint Surgery,Affiliated Hospital of Zunyi Medical University/Zunyi Medical University-University of Rochester Joint Orthopedic Research Center,Zunyi,Guizhou 563000,China)
出处
《重庆医学》
CAS
2022年第23期4078-4083,共6页
Chongqing medicine
基金
国家自然科学基金项目(81760400)
贵州省科技计划项目(黔科合支撑〔2018〕2760)。
关键词
药物支架材料
耐甲氧西林金黄色葡萄球菌
骨缺损
3D打印
骨感染
drug scaffold material
methicillin-resistant Staphylococcus aureus
bone defect
3D printing
bone infection
