摘要
目的 探究利奈唑胺用于与耐多药肺结核治疗的不良反应。方法 回顾性分析我院2020年1月至2021年12月期间45例应用利奈唑胺治疗出现不良反应的耐多药肺结核患者临床资料,统计其不良反应类型,分析其不良反应发生原因。结果 45例患者中,共发生不良反应51次,不良反应主要涉及神经系统(43.14%)、血液系统(35.29%)、代谢障碍(3.92%)、消化系统(13.73%)、皮肤及附件(3.92%),其中神经系统、血液系统不良反应发生率最高;不良反应类型比较中,其中不良反应发生率前3名分别为周围神经炎(31.37%)、血小板减少(22.53%)、恶心呕吐(9.80%);不良反应主要发生于治疗后1~3个月内,经停药或针对性治疗症状好转;男性不良反应发生率为58.82%,与女性41.18%相近(P> 0.05);年龄≤45岁不良反应发生率为54.90%,与> 45岁45.10%相近(P> 0.05);体质量≤60 kg不良反应发生率为64.71%,较体质量> 60 kg的35.29%高(P <0.05);起始用药剂量为600 mg(bid)不良反应发生率为76.47%,较600 mg(qd)的23.53%高(P <0.05);病程≤8个月不良反应发生率为47.06%,与> 8个月的52.91%相近(P> 0.05)。结论 利奈唑胺在对耐多药肺结核治疗中,不良反应多发生于治疗后1~3个月内,周围神经炎、血小板减少、恶心呕吐为主要不良反应,严重不良反应主要为视神经炎、血液系统、肝损伤、乳酸酸中毒,不同体质量、起始用药剂量均会影响不良反应发生率。
Objective To explore the adverse effects of linezolid in the treatment of multidrug-resistant pulmonary tuberculosis.Methods The clinical data of 45 patients with MDR-TB treated with linezolid from January 2020 to December 2021 were retrospectively analyzed.The types of adverse reactions and the causes of adverse reactions were analyzed.Results Among the 45 patients,51 adverse reactions occurred.The adverse reactions mainly involved nervous system(43.14%),blood system(35.29%),metabolic disorder(3.92%),digestive system(13.73%),skin and accessories(3.92%).The incidence of adverse reactions in nervous system and blood system was the highest;In the comparison of adverse reaction types,the top three adverse reaction rates were peripheral neuritis(31.37%),thrombocytopenia(22.53%),nausea and vomiting(9.80%);The adverse reactions mainly occurred within 1-3 months after treatment,and the symptoms improved after drug withdrawal or targeted treatment;The incidence of adverse reactions in males was 58.82%,which was similar to that in females(41.18%)(P>0.05);At age≤45 years old,the incidence of adverse reactions was 54.90%,which was similar to 45.10%of>45 years old(P>0.05);The incidence of adverse reactions was 64.71%when the weight was≤60 kg,which was higher than 35.29%when the weight was>60 kg(P<0.05);The adverse reaction rate was 76.47%when the initial dosage was 600 mg(bid),which was higher than that of 23.53%when the dosage was 600 mg(qd)(P<0.05);The incidence of adverse reactions was 47.06%when the course of disease was≤8 months,which was similar to 52.91%when the course of disease was>8 months(P>0.05).Conclusion In the treatment of MDR-TB,the adverse reactions of linezolid mostly occurred within 1-3 months after treatment.Peripheral neuritis,thrombocytopenia,nausea and vomiting were the main adverse reactions.The serious adverse reactions were mainly optic neuritis,blood system,liver injury,and lactic acid poisoning.Different body weight and initial dose of medication would affect the incidence of adverse reactio
作者
周付成
王家猛
陈茂伟
ZHOU Fucheng;WANG Jiameng;CHEN Maowei(Suqian Zhongwu Hospital,Suqian 223800,China)
出处
《中国医药指南》
2022年第33期80-82,86,共4页
Guide of China Medicine
关键词
耐多药肺结核
利奈唑胺
不良反应
Multidrug resistant pulmonary tuberculosis
Linezolid
Adverse reaction
