摘要
Through a meta-analysis,we comprehensively evaluated the clinical efficacy and safety of Kangfuxin liquid(KFXL)in patients with recurrent aphthous stomatitis(RAS).Randomized controlled clinical trials(RCTs)involving RAS patients treated with KFXL were systematically retrieved from several online databases from inception to December 2021.All the study selection,data extraction,and quality assessments were performed by two independent investigators using the Cochrane systematic review method.The total effective rate,VAS pain score,recurrence rate,and ulcer healing time were analyzed using Rev Man 5.3 software and Stata 16.0.A total of 17 studies consisting of 1703 patients were included in our investigation.The pooled result indicated that when compared with watermelon frost spray(WFS),KFXL had a significantly superior clinical effectiveness rate(logRR=0.19,95%CI:0.15 to 0.22,P<0.00001).Moreover,the ulcer healing time(MD=–1.63,95%CI=–2.32 to–0.93,P<0.00001),VAS pain score(MD=–1.81,95%CI:–2.65 to–0.97,P=0.00),and recurrence rate(logRR=–0.65,95%CI=–0.89 to 0.42,P<0.00001)of patients with RAS were also significantly improved after receiving the KFXL therapy.Our study revealed that KFXL was a more effective treatment for RAS than WFS,and it could significantly decrease the VAS pain score,recurrence rate,and ulcer healing time in patients.However,our study was limited by the quality of available literature,and further robust trials are needed for a more accurate analysis.
本文通过meta分析综合评价康复新液治疗复发性口腔溃疡(RAS)的临床疗效和安全性。我们从几个网络数据库中检索了使用康复新液治疗RAS患者的随机对照临床试验(RCT),检索时限均自建库起至2021年12月。由两位研究者独立进行文献纳入、筛选、数据提取及质量评估。结果共纳入了17项研究1703名患者,研究采用Revman5.3软件和Stata16.0软件进行分析。Meta分析结果显示康复新液在总有效率、VAS疼痛评分、复发率、溃疡愈合时间方面优于西瓜霜喷剂,并且具有很高的安全性。同时敏感性分析结果表明纳入数据结果的稳健性。虽然对总有效率和溃疡愈合时间结果被证明未存在发表偏倚,鉴于纳入研究的方法学质量存在选择性偏倚的可能性,期待纳入更多高质量文献进一步验证结论。
基金
Hebei province administration of traditional Chinese Me dicine(Grant No.2019141)。
