摘要
目的:从流行病学角度分析食管癌发生相关因素,为食管癌的防治以及食管癌中医病因病机理论的完善提供依据。方法:通过文献数据和专家论证设计调查统计表,内容由居住环境、文化程度、精神因素、饮用水情况、调查质量评价等9个方面,共54个小题组成;在全国食管癌高发地区建立河南、山西、河北、安徽、甘肃、四川、江苏、山东、陕西、新疆等10个研究中心,河南省又建立11个分中心,对10个研究中心包括11个分中心医院收住的食管癌患者进行调查,对调查结果进行统计分析,无序分类变量采用χ^(2)检验,多因素Logistic回归分析探究食管癌危险因素的独立性。结果:纳入食管癌患者2027例,非食管癌随机对照人群1991人。食管癌患者与非食管癌人群的婚姻状况、居住环境、受教育程度、劳动强度、婚姻状况等方面比较,差异有统计学意义(P<0.01)。食管癌患者农村人群、小学及以下学历、无劳动强度与重劳动强度者、离异与丧偶人数及接触农药者例数多于随机组。结论:居住环境、婚姻状况、文化程度、劳动强度均为食管癌发生的统计学相关因素,其中居住环境、受教育程度、婚姻状况、劳动强度、是否接触农药、饮用水是食管癌发生的危险因素。
Objective:To analyze the related factors of esophageal carcinoma(EC)from an epidemiological point of view,and to provide a basis for the prevention and treatment of EC and the improvement of the theory of etiology and pathogenesis of EC in traditional Chinese medicine.Methods:A survey statistical table was designed through literature data and expert argumentation.The content was composed of 9 aspects including living environment,educational level,spiritual factors,drinking water conditions,and survey quality evaluation,with a total of 54 sub-questions.Established 10 research centers in Henan,Shanxi,Hebei,Anhui,Gansu,Sichuan,Jiangsu,Shandong,Shaanxi,and Xinjiang in areas with high EC incidence across the country,and established 11 branch centers in Henan Province.The EC patients admitted to 10 research centers,including 11 sub-center hospitals,were investigated,and the results of the survey were statistically analyzed.The unordered categorical variables were analyzed byχ^(2) test,and multivariate logistic regression analysis was used to explore the independence of EC risk factors.Results:A total of 2027 patients with EC and 1991 non-EC randomized control populations were included.There were significant differences in marital status,living environment,education level,labor intensity,and marital status between EC patients and non-EC populations(P<0.01).Among EC patients,the number of rural populations,primary school education and below,those with no labor intensity and heavy labor intensity,the number of divorced and widowed persons,and the number of people exposed to pesticides were more than those in the random group.Conclusion:Living environment,marital status,educational level,and labor intensity are all statistically related factors for the occurrence of EC.Among them,living environment,education level,marital status,labor intensity,exposure to pesticides,and drinking water are the risk factors for the occurrence of EC.
作者
陈玉龙
郑玉玲
宋学坤
马纯政
代民涛
解英
舒琦瑾
薛文翰
徐学琴
董玉琼
李平
周超峰
范焕芳
罗保平
郑智
李晓龙
张洪亮
许彦超
李小青
王泽坤
朱然培
张华
周哲旭
张帆
张瑞
CHEN Yulong;ZHENG Yuling;SONG Xuekun;MA Chunzheng;DAI Mintao;XIE Ying;SHU Qijin;XUE Wenhan;XU Xueqin;DONG Yuqiong;LI Ping;ZHOU Chaofeng;FAN Huanfang;LUO Baoping;ZHENG Zhi;LI Xiaolong;ZHANG Hongliang;XU Yanchao;LI Xiaoqing;WANG Zekun;ZHU Ranpei;ZHANG Hua;ZHOU Zhexu;ZHANG Fan;ZHANG Rui(Henan University of Chinese Medicine,Zhengzhou Henan China 450046;The Second Affiliated Hospital of Henan University of Chinese Medicine/Henan Province Hospital of Traditional Chinese Medicine,Zhengzhou Henan China 450002;Shanxi Provincial Cancer Hospital,Taiyuan Shanxi China 030013;Zhejiang Provincial Hospital of Chinese Medicine,Hangzhou Zhejiang China 310006;Gansu Provincial Cancer Hospital,Lanzhou Gansu China 730000;The First Affiliated Hospital Of Anhui Medical University,Hefei Anhui China 230000;Hebei Province Hospital of Traditional Chinese Medicine,Shijiazhuang Hebei China 050000;Hubei Province Hospital of Traditional Chinese Medicine,Wuhan Hubei China 430061;Jiangxi Cancer Hospital,Nanchang Jiangxi China 330029;Ningxia Chinese Medicine Research Center,Yinchuan Ningxia China 750021;Traditional Chinese Medicine Hospital of Xinjiang Uygur Autonomous Region,Wulumuqi Xinjiang China 830000)
出处
《中医学报》
CAS
2022年第12期2598-2602,共5页
Acta Chinese Medicine
基金
国家中医临床研究基地科研专项资助项目(2019JD-ZX001)
国家中医临床研究基地科研专项资助项目(2019JDZX028)
河南省高等学校重点科研项目(20A360005)
河南省科技攻关社会发展项目(202102310497)
国家中医药百千万人才支持计划-岐黄学者资助项目{国中医药人教发〔2018〕284号}。
关键词
食管癌
社会环境因素
流行病学
esophageal carcinoma
social environmental factor
epidemiology
