摘要
目的:探讨外周血中性粒细胞与淋巴细胞比值(NLR)、淋巴细胞与单核细胞比值(LMR)对患儿急性髓系白血病(AML)疗效及预后的评估价值。方法:纳入97例AML患儿为AML组,并选取同期一般资料相匹配的体检健康儿童90例为对照组。根据血常规计算NLR、LMR水平。比较两组初诊时实验室指标,包括白细胞计数(WBC)、NLR、LMR、血红蛋白和血小板计数。比较AML患儿初诊时与治疗1个疗程后NLR、LMR水平。根据初诊时NLR、LMR水平将AML患儿分为NLR高表达组(46例)与NLR低表达组(51例)、LMR高表达组(53例)与LMR低表达组(44例),分析NLR、LMR水平与AML患儿临床特征及实验室指标的相关性,并比较不同NLR、LMR水平AML患儿短期疗效。采用Kaplan-Meier法分析NLR、LMR水平与AML患儿预后的关系。结果:与对照组相比,AML组患儿WBC、NLR水平升高,LMR、血红蛋白、血小板计数水平降低(均P<0.05)。与初诊时相比,治疗1个疗程后AML患儿NLR水平降低,LMR水平升高(均P<0.05)。NLR、LMR水平与AML患儿性别、年龄、WBC、血红蛋白、血小板计数无相关性(均P>0.05)。NLR低表达组完全缓解(CR)率高于NLR高表达组,LMR高表达组CR率高于LMR低表达组(均P<0.05)。NLR高表达组3年无复发生存率低于NLR低表达组,LMR高表达组3年无复发生存率高于LMR低表达组(均P<0.05)。结论:外周血NLR、LMR水平对AML患儿疗效及长期预后具有良好的评估价值。
Objective:To explore the value of peripheral blood neutrophil to lymphocyte ratio(NLR)and lymphocyte to monocyte ratio(LMR)in evaluating the efficacy and prognosis of children with acute myeloid leukemia(AML).Methods:A total of 97 children with AML were included as AML group,and anotheR90 healthy children who matched the general data were regarded as the control group.The NLRand LMRwere calculated according to the blood routine.Laboratory parameters at the time of initial diagnosis,including WBC,NLR,LMR,hemoglobin and platelet count,were compared between two groups.The levels of NLRand LMRin children with AML at the time of initial diagnosis and afteRone course of treatment were compared.Children with AML were divided into high NLRexpression group(46 cases)and low NLRexpression group(51 cases),high LMRexpression group(53 cases)and low LMRexpression group(44 cases)according to NLRand LMRlevels at the time of initial diagnosis,and the correlation between NLR,LMRlevels and clinical characteristics and laboratory parameters of children with AML was analyzed,and the short-term efficacy of children with AML at different NLRand LMRlevels was compared.The Kaplan-MeieRmethod was used to analyze the relationship between NLR,LMRlevels and the prognosis of children with AML.Results:Compared with the control group,the levels of WBC and NLRin AML group increased,and the levels of LMR,hemoglobin and platelet count decreased(all P<0.05).AfteRone course of treatment,the level of NLRwas decreased and the level of LMRwas increased in children with AML compared with those at the time of initial diagnosis(all P<0.05).There was no correlation between NLR,LMRlevels and sex,age,WBC,hemoglobin and platelet count in children with AML(all P>0.05).The rate of complete remission(CR)in low NLRexpression group was higheRthan that in high NLRexpression group,and the CRrate in high LMRexpression group was higheRthan that in low LMRexpression group(all P<0.05).The 3-yeaRrelapse-free survival rate in high NLRexpression group was loweRthan that in
作者
李妍
张合成
王国锋
范朋凯
LI Yan;ZHANG Hecheng;WANG Guofeng;FAN Pengkai(Blood Disease Laboratory,Children’s Hospital Affiliated to Zhengzhou University,Zhengzhou 450002,China)
出处
《陕西医学杂志》
CAS
2022年第12期1516-1519,共4页
Shaanxi Medical Journal
基金
河南省医学科技攻关计划联合共建项目(LHGJ20210659)。
