摘要
目的重症医学科(ICU)脓毒症患者血清炎症因子水平与多器官功能障碍综合征(MODS)的关系。方法选择2020年1月—2021年6月在西宁市第一人民医院ICU中治疗的64例脓毒症患者作为研究对象,根据患者在ICU期间是否发生MODS将其分为MODS组(34例)和对照组(30例)。于患者确诊脓毒症后1 d检测两组血清降钙素原(PCT)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、白细胞介素-10(IL-10)水平。以ROC曲线分析PCT、TNF-α、IL-6、IL-10预测脓毒症患者发生MODS的价值;以Spearman系数分析PCT、TNF-α、IL-6、IL-10与脓毒症患者发生MODS的相关性。结果与对照组相比,MODS组PCT、TNF-α、IL-6水平较高,IL-10水平较低,差异有统计学意义(P<0.05);经ROC分析,PCT≥6.539 ng/mL、TNF-α≥133.887 mg/L、IL-6≥156.785 ng/L、IL-10≤61.419 ng/L是预测脓毒症患者发生MODS的最佳截断值,差异有统计学意义(P<0.05);血清PCT、TNF-α、IL-6与ICU患者发生MODS呈正相关,IL-10与ICU患者发生MODS呈负相关,差异有统计学意义(P<0.05)。结论脓毒症患者发生MODS后血清PCT、TNF-α、IL-6水平明显升高,IL-10水平明显降低,血清PCT、TNF-α、IL-6与ICU患者发生MODS呈正相关,IL-10与ICU患者发生MODS呈负相关。
Objective To investigate the correlations of serum inflammatory factors and the risk of multiple organ dysfunction syndrome(MODS)in patients with sepsis.Methods A total of 64 patients with sepsis who were treated in ICU of Xining First People's Hospital from January 2020 to June 2021 were selected as the study subjects.According to whether MODS occurred in ICU,the patients were divided into MODS group(34 cases)and control group(30 cases).Fasting peripheral venous blood samples were collected fromthe 64 patients in the next morning after admission to test the procalcitonin(PCT),tumor necrosis factor-α(TNF-α),interleukin(IL-6)and interleukin(IL-10).ROC was used to analyze the values of PCT,TNF-α,IL-6 and IL-10 in predicting the occurrence of MODS in sepsis patients.Spearman coefficient was used to analyze the correlation of PCT,TNF-α,IL-6,and IL-10 with MODS.Results The levels of PCT,TNF-α,and IL-6 of the MODS group were all significantly higher than those of the control group(all P<0.05),while the level of IL-10 of the MODS group was significantly lower than that of the control group(P<0.05).According to the ROC analysis,PCT≥6.539 ng/mL,TNF-α≥133.887 mg/L,IL-6≥156.785 ng/L,and IL-10≤61.419 ng/L were the best cut-off values for predicting the occurrence of MODS in sepsis patients,with statistically significant differences(all P<0.05).Serum PCT,TNF-αand IL-6 were positively correlated with,while IL-10 was negatively correlated with MODS in sepsis patients,with statistical significance(all P<0.05).Conclusion The serum levels of PCT,TNF-α and IL-6 are significantly increased and the level of IL10 is significantly decreased in septic patients complicated with MODS.The serum levels of PCT,TNF-α,and IL-6 are positively,while IL-10 level is negatively correlated with septic patients complicated.
作者
何凤棣
宋贵芳
冶秀花
苏延娟
罗雯静
马永春
包小燕
HE Fengdi;SONG Guifang;YE Xiuhua;SU Yanjuan;LUO Wenjing;MA Yongchun;BAO Xiaoyan(Department of Intensive Care Medicine,Xining First People's Hospital,Xining Qinghai 810000,China)
出处
《中国急救复苏与灾害医学杂志》
2022年第11期1458-1461,共4页
China Journal of Emergency Resuscitation and Disaster Medicine
基金
青海省自然科学基金项目(编号:20160112)。
关键词
重症医学科
脓毒症
多器官功能障碍综合征
炎症因子
Intensive care unit
Sepsis
Multiple organ dysfunction syndrome
Inflammatory cytokines
