摘要
Cardiovascular diseases(CVD)have become..the leading cause of morbidity and mortality worldwide.Duringthe past two,decades,many experimental and preclinical studies have highlighted the critical roles of histone modifications(eg,acetylations and methylations)in regulating cardiovas-cular development,homeostasis,and disease progression by regulating gene transcription.The well studied histone acetylations such as H3K9ac and H3K27ac activate gene transcription and have shown critical functions in cardio-vascular homeostasis and remodeling. For instance,while class Ⅰ and Ⅱ histone deacetylases(HDACs)generally promote the development of cardiac hypertrophy and diabetic cardiomyopathy,most class Ⅱ HDACs(Sirtuins)exhibit cardioprotective capacity.The inhibitors of class Ⅲ HDACs have been proven to repress cardiac remodeling and heart failure.
基金
supported by the National Natural Science FoundationofChina(grantnumbers:,81970426,81800273,and 82004097)
theYoung Elite Scientists Sponsorship Program of China Association for Science and Technology(grant_number:2018QNRC001)
the Scientific and Technological Innovation Talents Program of SichuanProvince(grantnumber:2020JDRC0017)
the China Postdoctoral Science Foundation(grant number:2020M673163).
