摘要
肺动脉高压是由多种已知或未知病因引起的肺动脉压异常升高的一种病理生理状态。其发病机制涉及过度的血管收缩、血管重塑、炎症和原位血栓形成等。血小板直接与血管接触, 在调控血管功能方面发挥着重要的作用。最近的研究发现血小板可能参与肺动脉高压发生、发展过程。本文从血小板参与血栓形成、分泌细胞因子间接或直接作用于血管等途径探讨其参与肺动脉高压发生、发展的机制。
Pulmonary hypertension(PH)is a pathophysiological condition of abnormally elevated pulmonary artery pressure resulting from known and unknown causes.The pathogenesis of PH involves excessive vasoconstriction,vascular remodeling,inflammation and in situ thrombosis.Platelets are directly exposed to blood vessels and play an important role in regulating vascular function.Platelets are involved in the occurrence and development of pulmonary hypertension in recent studies.The mechanism of platelets involvement in the occurrence and development of PH is analyzed in this paper by means of thrombus formation and indirect or direct action of cytokine secretion on blood vessels.
作者
韦依宁
陈慧婉
刘淑婷
梁珊珊
叶凯文
唐瑞娣
王涛
Wei Yining;Chen Huiwan;Liu Shuting;Liang Shanshan;Ye Kaiwen;Tang Ruidi;Wang Tao(The First Clinical College,Guangzhou Medical University,Guangzhou 510180,China;The Second Clinical College,Guangzhou Medical University,Guangzhou 510180,China;Department of Pulmonary and Critical Care Medicine,State Key Laboratory of Respiratory Disease,the First Affiliated Hospital of Guangzhou Medical University,Guangzhou 510120,China)
出处
《国际呼吸杂志》
2022年第19期1491-1497,共7页
International Journal of Respiration
基金
国家自然基金项目(81970046)。
关键词
肺动脉高压
血小板
血管重塑
Pulmonary hypertension
Platelet
Vascular remolding
