摘要
目的探究氨溴特罗联合复方异丙托溴铵治疗小儿肺炎的临床效果。方法选择我院2018年2月至2021年2月收治的76例肺炎患儿作为研究对象,按照奇偶数法将其分为对照组(38例,氨溴特罗)和研究组(38例,氨溴特罗+复方异丙托溴铵)。比较两组的治疗效果。结果治疗7 d后,两组的用力肺活量(FVC)、每千克体重潮气量(TV/kg)及达峰时间比(TPTEF/TE)均增大,且研究组大于对照组(P<0.05)。治疗7 d后,两组的半胱氨酰白三烯(CysLTs)、嗜酸粒细胞阳离子蛋白(ECP)、粒细胞巨噬细胞集落刺激因子(GM-CSF)、嗜酸性粒细胞趋化蛋白(Eotaxin)、白细胞介素-2受体(SIL-2R)水平均降低,且研究组低于对照组(P<0.05)。研究组的不良反应总发生率为7.89%,低于对照组的23.68%(P<0.05)。结论氨溴特罗联合复方异丙托溴铵治疗小儿肺炎的临床效果显著,对于通气功能的改善具有促进作用,有利于调节血清指标,且不良反应少,临床可进一步推广应用。
Objective To explore the clinical effect of ambroxol combined with compound ipratropium bromide in the treatment of pneumonia in children.Methods A total of 76 children with pneumonia admitted in our hospital from February2018 to February 2021 were selected as the research objects.According to the odd-even method,the children were divided into control group(38 cases,ambroxol)and study group(38 cases,ambroxol+compound ipratropium bromide).The therapeutic effects of the two groups were compared.Results After 7 d of treatment,the forced vital capacity(FVC),tidal volume/kg(TV/kg)and ratio of the time to reach peak tidal expiratory flow to total expiratory time(TPTEF/TE)in the two groups increased,and those in the study group were higher than the control group(P<0.05).After 7 d of treatment,the levels of cysteinyl leukotrienes(CysLTs),eosinophil cationic protein(ECP),granulocyte macrophage colony factor(GM-CSF),Eotaxin and soluble interleukin-2 receptor(SIL-2R)in the two groups decreased,and those in the study group were lower than the control group(P<0.05).The total incidence of adverse reactions in the study group was 7.89%,which was lower than 23.68%in the control group(P<0.05).Conclusion Ambroxol combined with compound ipratropium bromide in the treatment of pneumonia in children has a significant clinical effect,it can promote the improvement of ventilation function,help to regulate serum indicators,and has fewer adverse reactions.It can be further promoted and applied in clinic.
作者
卢山
刘亚丽
LU Shan;LIU Yali(Pediatric Department,Pingqiao District Hospital of Traditional Chinese Medicine,Xinyang 464094;Pediatric Department,Xinyang Central Hospital,Xinyang 464000,China)
出处
《临床医学研究与实践》
2022年第33期115-117,共3页
Clinical Research and Practice
关键词
小儿
肺炎
氨溴特罗
复方异丙托溴铵
不良反应
children
pneumonia
ambroxol
compound ipratropium bromide
adverse reaction
