摘要
血管性痴呆(VaD)是仅次于阿尔茨海默病的第二大常见痴呆类型。针对VaD机制与相关药物的研究具有重大价值和社会意义。VaD发生发展过程中伴随着不同程度的氧化损伤,包括氧化产物的增加和抗氧化能力的下降等。作者对活性氧、活性氧与VaD的关系以及VaD抗氧化治疗的研究进展进行了综述。
Vascular dementia is the second most common type of dementia after Alzheimer′s disease. The researches on its mechanisms and the development of related drugs have great research value and social significance. The occurrence and development of vascular dementia is accompanied by different degrees of oxidative damage, including the increase of oxidation products and the decline of antioxidant capacity. This paper introduced reactive oxygen species and reviewed the research progress on relationship between reactive oxygen species and vascular dementia, and the antioxidant therapy for vascular dementia.
作者
周佳琪
刘勇
夏浩楠
宫晓洋
高玉玲
原亚利
李选
Zhou Jiaqi;Liu Yong;Xia Haonan;Gong Xiaoyang;Gao Yuling;Yuan Yali;Li Xuan(Department of Rehabilitation Medicine,the First Affiliated Hospital of Dalian Medical University,Dalian 116011,China)
出处
《中国脑血管病杂志》
CAS
CSCD
北大核心
2022年第11期788-791,共4页
Chinese Journal of Cerebrovascular Diseases
基金
辽宁省自然科学基金(2021-MS-282)
辽宁省教育厅科学研究经费项目(LJKZ1367)
辽宁省优秀中医临床人才项目(辽卫办发[2021]29号)。
关键词
活性氧
痴呆
血管性
认知障碍
治疗
综述
Reactive oxygen species
Dementia
vascular
Cognition disorders
Treatment
Review
