摘要
人脑基本生理活动及认知功能需要精确的脑血流调控机制以供应充足的氧和葡萄糖,神经血管耦合(NVC)作为实现脑内血流自主调控的重要机制,具有多通路、响应迅速的特点。作者总结了皮质内、皮质下、节后神经元等3种NVC调节的基本生理机制,论述了缺血、缺氧等病理状态与NVC功能障碍的关系,并对NVC未来机制研究的方向进行了展望,以期对临床治疗脑血管疾病提供新的思路和靶点。
The neural activity and cognitive function require sophisticated regulation of blood flow in order to supply enough oxygen and glucose to the human brain.As a vital mechanism of cerebral blood flow autoregulation,neurovascular coupling(NVC)has characteristics of multiple channels and rapid response.Three physiological mechanisms in cortex,subcortex and postganglion were summarized,and the relationship between ischemia or hypoxia and NVC dysfunction was discussed in this article.In addition,the prospect of NVC mechanism study was addressed so as to provide new idea and target for treating cerebrovascular diseases.
作者
马思明
汪露
杨静雯
曹燕
苏鑫童
刘存志
Ma Siming;Wang Lu;Yang Jingwen;Cao yan;Su Xintong;Liu Cunzhi(Department of Acupuncture,Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University,Beijing 100010,China;不详)
出处
《中国脑血管病杂志》
CAS
CSCD
北大核心
2019年第12期667-672,共6页
Chinese Journal of Cerebrovascular Diseases
基金
国家自然科学基金面上项目(81774396)
关键词
神经血管耦合
脑血流
自发调节
脑血管病
综述
Neurovascular coupling
Cerebral blood flow
Autoregulation
Cerebrovascular disease
Review
