摘要
目的 探讨血清成纤维细胞生长因子9(fibroblast growth factor 9,FGF9)、神经肽Y(neuropeptide Y,NPY)对双相情感障碍的临床诊断价值。方法 选择2019年2月至2022年2月于绍兴市第七人民医院治疗的94例双相情感障碍患者纳入观察组,其中抑郁发作26例(抑郁发作组),躁狂发作25例(躁狂发作组),混合发作43例(混合发作组);另选择同期健康体检者90例纳入对照组。收集研究对象的汉密尔顿抑郁量表(Hamilton depression scale,HAMD)评分、杨氏躁狂状态评定量表(Young mania rating scale,YMRS)评分等临床资料,采用酶联免疫吸附测定法检测血清FGF9、NPY水平;Pearson相关分析用于评估不同临床类型双相情感障碍患者的血清FGF9、NPY水平与HAMD评分、YMRS评分的相关性;绘制受试者操作特征曲线分析血清FGF9、NPY水平对双相情感障碍的诊断效能。结果 观察组患者的血清FGF9水平显著高于对照组,NPY水平显著低于对照组(P<0.05)。抑郁发作组、躁狂发作组和混合发作组患者的血清FGF9水平依次升高,NPY水平依次降低(P<0.05)。抑郁发作、躁狂发作、混合发作双相情感障碍患者的血清FGF9水平与HAMD评分、YMRS评分均呈正相关(P<0.05),NPY水平与HAMD评分、YMRS评分均呈负相关(P<0.05)。血清FGF9、NPY水平及二者联合诊断双相情感障碍的曲线下面积分别为0.846、0.811、0.920,敏感度分别为68.1%、76.6%、76.7%,特异性分别为90.0%、73.3%、93.3%。结论 双相情感障碍患者的血清FGF9水平升高,NPY水平降低,二者可作为诊断双相情感障碍的辅助指标。
Objective To investigate the clinical diagnostic value of serum fibroblast growth factor 9(FGF9) and neuropeptide Y(NPY) for bipolar disorder. Methods Ninety-four patients with bipolar disorder who treated in Shaoxing Seventh People’s Hospital from February 2019 to February 2022 were regarded as observation group,including 26 cases of depressive episode(depressive episode group), 25 cases of manic episode(manic episode group),and 43 cases of mixed episode(mixed episode group);meantime, 90 healthy subjects were regarded as control group.The clinical data such as Hamilton depression scale(HAMD) score and Young mania rating scale(YMRS) score were collected;enzyme-linked immunosorbent assay was applied to determine the levels of serum FGF9 and NPY. Pearson correlation was applied to analyze the correlation of levels of serum FGF9 and NPY with HAMD score and YMRS score in patients with different clinical types of bipolar disorder;receiver operating characteristic curve was drawn to analyze the diagnostic efficacy of levels of serum FGF9 and NPY for bipolar disorder. Results The level of serum FGF9 in observation group was obviously higher than that in control group, and the level of NPY was obviously lower than that in control group(P<0.05). The level of serum FGF9 in patients with bipolar disorder in depressive episode group, the manic episode group and the mixed episode group was sequentially increased, and the level of NPY was sequentially decreased(P<0.05). The level of serum FGF9 was positively correlated with HAMD score and YMRS score in patients with bipolar disorder of depressive episode, manic episode, and mixed episode(P<0.05),while NPY was negatively correlated with HAMD score and YMRS score(P<0.05). The area under the curve of levels of serum FGF9 and NPY and their combined diagnosis of bipolar disorder was 0.846, 0.811, and 0.920,respectively, with sensitivity of 68.1%, 76.6%, and 76.7%, respectively, and specificity of 90.0%, 73.3%, and 93.3%,respectively. Conclusion The serum FGF9 level is increased a
作者
黄磊
郑春美
庞卢伟
赵云飞
蒋海潮
冯虹
HUANG Lei;ZHENG Chunmei;PANG Luwei;ZHAO Yunfei;JIANG Haichao;FENG Hong(Department of Psychiatry,Shaoxing Seventh People’s Hospital,Zhejiang,Shaoxing 312000,China)
出处
《中国现代医生》
2022年第28期15-19,共5页
China Modern Doctor
基金
浙江省医药卫生科技计划项目(2019KY231,2022RC279)。
