摘要
肝纤维化是各种慢性肝病进展的必经阶段,最终会演化至肝硬化甚至肝癌。病毒性肝炎是导致肝纤维化的最主要原因,抗病毒治疗对病毒性肝炎的血清学转化及肝纤维化的逆转有着重要作用。本文总结归纳了抗病毒治疗对肝纤维化病理学逆转的作用、相关的分子机制以及目前仍存在的局限,以期为后续的相关临床与基础研究提供一定的参考。
As an inevitable stage in the progression of various chronic liver diseases,liver fibrosis eventually develops into liver cirrhosis or cancer.Because viral infection is a major cause of liver fibrosis,antiviral therapy is critical in the seroconversion and reversal of liver fibrosis in viral hepatitis.This review summarizes the clinical effects and underlying molecular mechanisms of antiviral therapy in the pathological reversal of liver fibrosis,as well as the current limitations,with the goal of providing literature references for upcoming clinical and basic research.
作者
罗昕
曲颖
蔡晓波
陆伦根
LUO Xin;QU Ying;CAI Xiaobo;LU Lungen(Department of Gastroenterology,Shanghai General Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200080,China)
出处
《临床肝胆病杂志》
CAS
北大核心
2022年第11期2596-2598,共3页
Journal of Clinical Hepatology
关键词
肝硬化
抗病毒药
病理过程
Liver Cirrhosis
Antiviral Agents
Pathologic Processes
