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Long-term follow-up of cumulative incidence of hepatocellular carcinoma in hepatitis B virus patients without antiviral therapy 被引量:6

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摘要 BACKGROUND China has a high prevalence of hepatitis B virus(HBV),but most chronic hepatitis B(CHB)patients do not receive standardized antiviral therapy.There are few relevant reports addressing the outcomes of the large number of CHB patients who do not receive antiviral therapy.AIM To observe the outcomes of long-term follow-up of patients with CHB without antiviral treatment.METHODS This study included 362 patients with CHB and 96 with hepatitis B cirrhosis without antiviral treatment and with only liver protection and anti-inflammatory treatment from 1993 to 1998.The median follow-up times were 10 and 7 years,respectively.A total of 203 CHB and 129 hepatitis B cirrhosis patients receiving antiviral therapy were selected as the control groups.The median follow-up times were 8 and 7 years,respectively.Kaplan-Meier curves were used to analyze the cumulative incidence of hepatocellular carcinoma(HCC),and the Cox regression model was used to analyze the risk factors for HCC.RESULTS Among the patients in the non-antiviral group,16.9%had spontaneous decreases(HBeAg)seroconversion.In the antiviral group,87.2%of patients had undetectable HBV DNA,and 52%showed HBeAg seroconversion.Among CHB and hepatitis B cirrhosis patients,the cumulative incidence rates of HCC were 14.9%and 53.1%,respectively,in the non-antiviral group and were 10.7%and 31.9%,respectively,in the antiviral group.There was no difference between the two groups regarding the CHB patients(P=0.842),but there was a difference between the groups regarding the hepatitis B cirrhosis patients(P=0.026).The cumulative incidence rates of HCC were 1.6%and 22.3%(P=0.022)in the groups with and without spontaneous HBeAg seroconversion,respectively.The incidence rates of HCC among patients with and without spontaneous declines in HBV DNA to undetectable levels were 1.6%and 19.1%,respectively(P=0.051).There was no difference in the cumulative incidence of HCC between the two groups regarding the patients with drug-resistant CHB(P=0.119),but there was a significant diffe
出处 《World Journal of Gastroenterology》 SCIE CAS 2021年第11期1101-1116,共16页 世界胃肠病学杂志(英文版)
基金 National Natural Science Foundation of China,No.81174263 Sanming Project of Medicine in Shenzhen,Guangdong Province,China,No.SZSM201612074 Shenzhen Science and Technology Project,Guangdong Province,China,No.201202154.
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  • 1Wang, Jian,Zhao, Jin-Hong,Wang, Ping-Ping,Xiang, Gui-Ju.Expression of CXC chemokine IP-10 in patients with chronic hepatitis B[J].Hepatobiliary & Pancreatic Diseases International,2008,7(1):45-50. 被引量:36
  • 2Jung MC,Spengler U,Schraut W,Hoffmann R,Zachoval R,Eisenburg J,Eichenlaub D,Riethmüller G,Paumgartner G,Ziegler-Heitbrock HW.Hepatitis B virus antigen-specifi c T-cell activation in patients with acute and chronic hepatitis. B. J Hepatol . 1991 被引量:1
  • 3Freeman GJ,Long AJ,Iwai Y,Bourque K,Chernova T,Nishimura H,Fitz LJ,Malenkovich N,Okazaki T,Byrne MC,Horton HF,Fouser L,Carter L,Ling V,Bowman MR,Carreno BM,Collins M,Wood CR,Honjo T.Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. The Journal of Experimental Medicine . 2000 被引量:1
  • 4Tong S.Mechanism of HBV genome variability and replication of HBV mutants. Journal of Clinical Virology . 2005 被引量:1
  • 5Malmgaard L.Induction and regulation of IFNs during viral infections. Journal of Interferon and Cytokine Research . 2004 被引量:1
  • 6Zeremski M,Petrovic LM,Chiriboga L,Brown QB,Yee HT,Kinkhabwala M,Jacobson IM,Dimova R,Markatou M,Talal AH.Intrahepatic levels of CXCR3-associated chemokines correlate with liver in? ammation and f ibrosis in chronic hepatitis C. Hepatology . 2008 被引量:1
  • 7J.L. Dienstag.Hepatitis B virus infection. The New England Journal of Medicine . 2008 被引量:1
  • 8Webster GJ,Reignat S,Maini MK,Whalley SA,Ogg GS,KingA,Brown D,Amlot PL,Williams R,Vergani D,Dusheiko GM,Bertoletti A.Incubation phase of acute hepatitis B in man: dynamic of cellular immune mechanisms. Hepatology . 2000 被引量:1
  • 9Grady,G. F.,Lee,V. A.,Prince,A. M.,Gitnick,G. L.,Fawaz,K. A.,Vyas,G. N.,Levitt,M. D.,Senior,J. R.,Galambos,J. T.,Bynum,T. E.,Singleton,J. W.,Clowdus,B. F.,Akdamar,K.,Aach,R. D.,Winkelman,E. I.,Schiff,G. M.,Hersh,T.Hepatitis B immune globulin for accidental exposures among medical personnel: Final report of a multicenter controlled trial. The Journal of Infectious Diseases . 1978 被引量:1
  • 10Penna A,Artini M,Cavalli A,Levrero M,Bertoletti A,Pilli M,Chisari FV,Rehermann B,Del Prete G,Fiaccadori F,Ferrari C.Long-lasting memory T cell responses following self-limited acute hepatitis B. J Clin Invest . 1996 被引量:1

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