摘要
目的评估血清降钙素原(PCT)、内毒素水平在感染性休克患者病情及预后中的应用价值。方法选取我院2019年1月-2021年6月急诊科收治的急性感染患者80例作为观察组,其中感染性休克和非感染性休克患者各40例。另选取同期来我院体检的健康者80名作为对照组。利用急性生理学和慢性健康状况评分系统Ⅱ(APACHEⅡ)对两组进行评分,检测PCT、内毒素水平以及APACHEⅡ评分,通过Logistic回归方法进行患者治疗预后影响因素分析,评估PCT、内毒素水平对于急性感染患者预测价值。结果观察组血清PCT、内毒素水平及APACHEⅡ评分高于对照组(P<0.05);感染性休克患者血清PCT、内毒素水平及APACHEⅡ评分高于非感染性休克患者(P<0.05);Logistic回归分析结果显示血清PCT、内毒素及APACHEⅡ评分是感染性休克患者预后的独立危险因素(P<0.05);血清PCT、内毒素水平预测急性感染患者的灵敏度、特异度以及约登指数均高于单一指标检测。结论血清PCT、内毒素水平对感染性休克患者的病情及预后具有重要的临床应用价值。
Objective To evaluate the application value of serum procalcitonin(PCT)and endotoxin levels in the condition and prognosis of patients with septic shock.Methods A total of 80 patients with acute infection admitted to the emergency department of our hospital from January 2019 to June 2021 were selected as the observation group,including 40 patients with septic shock and 40 patients with non-septic shock.In addition,80 healthy people who came to our hospital for physical examination during the same period were selected as the control group.The acute physiology and chronic health evaluation systemⅡ(APACHEⅡ)was used to score the two groups,and the levels of PCT,endotoxin and APACHE score were detected.Logistic regression method was used to analyze the prognostic factors of patients,and the predictive value of PCT and endotoxin levels for patients with acute infection was evaluated.Results The levels of serum PCT,endotoxin and APACHEⅡscore in the observation group were higher than those in the control group(P<0.05).The levels of serum PCT,endotoxin and APACHE II score in patients with septic shock were higher than those in patients with non-septic shock(P<0.05).Logistic regression analysis showed that serum PCT,endotoxin and APACHE II score were independent risk factors for the prognosis of patients with septic shock(P<0.05).The sensitivity,specificity and Youden index of serum PCT and endotoxin levels in predicting acute infection were higher than those of single index.Conclusion Serum PCT and endotoxin levels have important clinical application value for the condition and prognosis of patients with septic shock.
作者
陈磊
周旭瑜
毛海
CHEN Lei;ZHOU Xu-yu;MAO Hai(Department of Urology,Guangxin District People's Hospital,Shangrao 334100,Jiangxi,China;Department of Laboratory,Guangxin District People's Hospital,Shangrao 334100,Jiangxi,China)
出处
《医学信息》
2022年第18期65-67,共3页
Journal of Medical Information
基金
上饶市科技计划项目(编号:20202CKJ26)。
