摘要
目的探讨人乳头瘤病毒(human papilloma virus,HPV)感染后转阴的流行病学影响因素。方法收集2020年1月—2020年2月于山西医科大学第一医院就诊的511例HPV感染患者的资料,采用单因素和多因素logistic回归对HPV感染后转阴的影响因素进行分析。结果511例HPV感染患者中,244例(47.75%)患者表现为HPV感染后转阴(转阴组),267例(52.25%)患者表现为持续性感染(未转阴组)。睡眠评估结果显示,全部入组患者总体睡眠状况较差,SRSS平均得分为(26.23±5.75)分,其中失眠后的生理心理反应、睡眠时间不足、入睡困难得分较高。单因素分析结果显示,生物钟节律关键因素(年龄、近期睡眠、焦虑状态)以及性生活频率、妊娠次数、工作状态等与HPV感染后转阴有关(均P<0.05),其中转阴组中61.07%(149/244)的患者近期睡眠质量较差,未转阴组中81.27%(217/267)的患者报告近期睡眠质量较差,两组比较差异有统计学意义(P<0.001)。多因素logistic回归结果显示,近期睡眠质量和药物干预是HPV感染后转阴的独立影响因素,其中近期睡眠质量好是HPV感染后转阴的保护因素,睡眠质量好的患者HPV感染后转阴的概率升高1.861倍(OR=2.861,95%CI:1.735~4.715);在药物干预方面,应用瑞贝生(OR=0.444,95%CI:0.299~0.662)或干扰素(OR=0.080,95%CI:0.031~0.206)治疗更有利于HPV感染后转阴,相比较而言,瑞贝生效果更为理想。结论HPV感染患者普遍近期睡眠质量较差,生物钟节律关键因素睡眠质量、焦虑情况可影响HPV感染后转阴,改善近期睡眠质量并进行适当的精神疏导,有助于感染人群HPV病毒的清除。
Objective To investigate the epidemiologic factors influencing the negative conversion after human papilloma virus(HPV)infection.Methods The data of 511 patients with HPV infection treated in the First Hospital of Shanxi Medical University from January 2020 to February 2020 were collected,and the factors influencing the negative conversion after HPV infection were analyzed by using univariable and multifactoriallogistic regression.Results Among 511 patients with HPV infection,244(47.75%)patients showed negative conversion after HPV infection(conversion group)and 267(52.25%)patients showed persistent infection(non-conversion group).The results of sleep assessment showed that the overall sleep status of all enrolled patients was poor,with an average SRSS score of(26.23±5.75)point,in which the contributions of physiological and psychologicalreaction afterinsomnia,insufficientsleep time and difficulty in falling asleep were higher than other factors.Univariable analysis showed that the key factors including circadian rhythm(age,sleep quality,anxiety state),sexual frequency,pregnancy time and work status were associated with negative conversion after HPV infection(all P<0.05).In the conversion group,61.07%(149/244)of the patients reported poor recent sleep quality,while 81.27%(217/267)of the patients in the non-conversion group reported poor recent sleep quality.The difference between the two groups was statistically significant(P<0.001).Multivariable logistic regression showed that recent sleep quality and drug intervention were independent influencing factors of negative conversion after HPV infection.Good recent sleep quality was a protective factor of negative conversion after HPV infection,and the probability of negative conversion after HPV infection in patients with good sleep quality was 1.861 times higher(OR=2.861,95%CI:1.735-4.715).In terms of pharmacological interventions,the application of rebacin(OR=0.444,95%CI:0.299-0.662)or interferon(OR=0.080,95%CI:0.031-0.206)was more conducive to the negative conver
作者
王福媛
王朝霞
赵乐
辛利清
和思敏
王彤
WANG Fuyuan;WANG Zhaoxia;ZHAO Le;XIN Liqing;HE Simin;WANG Tong(Department of Gynecology,the First Hospital of Shanxi Medical University,2School of Public Health,Shanxi Medical University,Taiyuan 030001,China)
出处
《中国癌症防治杂志》
CAS
2022年第5期552-557,共6页
CHINESE JOURNAL OF ONCOLOGY PREVENTION AND TREATMENT
基金
山西省重点研发计划社发面上项目(201903D321145)。
关键词
宫颈癌
HPV感染
生物钟节律
睡眠
Cervical cancer
HPV infection
Circadian rhythm
Sleep
