摘要
目的探讨妊娠期糖尿病患者胎盘组织miR-20、miR-192的表达水平及其与新生儿窒息的关系。方法选取198例妊娠期糖尿病患者作为研究对象,根据其新生儿窒息情况分为新生儿窒息组和无新生儿窒息组。比较两组患者的临床资料及胎盘组织中miR-20、miR-192的表达水平。采用Logistic回归模型分析胎盘组织miR-20、miR-192表达水平与妊娠期糖尿病患者分娩的新生儿发生窒息的相关性。结果共23例新生儿发生窒息,新生儿窒息发生率为11.62%。新生儿窒息组胎盘组织miR-20、miR-192表达水平均高于无新生儿窒息组,且年龄≥35岁、未完全遵医嘱治疗、胎盘异常、脐带异常、羊水异常、分娩当日体质指数≥30 kg/m^(2)的孕妇比例亦高于无新生儿窒息组(P<0.05)。Logistic回归模型分析结果显示,年龄≥35岁、未完全遵医嘱治疗、胎盘异常、脐带异常、羊水异常、分娩当日体质指数≥30 kg/m^(2)、胎盘组织miR-20和miR-192表达水平升高均是妊娠期糖尿病患者分娩的新生儿发生窒息的危险因素(均P<0.05)。结论妊娠期糖尿病患者胎盘组织中miR-20、miR-192表达上调,两者可导致新生儿窒息的发生风险升高。
Objective To investigate the expressions of miR-20 and miR-192 in placental tissues of patients with gestational diabetes mellitus and their relation with neonatal asphyxia.Methods A total of 198 patients with gestational diabetes mellitus were selected as the research subjects,and they were assigned to neonatal asphyxia group or neonatal non-asphyxia group according to the condition of neonatal asphyxia.The clinical data,and expression levels of miR-20 and miR-192 in placental tissues were compared between the two groups.The Logistic regression model was performed to analyze the correlation of the expressions of miR-20 and miR-192 in placental tissues with asphyxia in newborns delivered by patients with gestational diabetes mellitus.Results There were 23 newborns suffering from asphyxia in total,with the incidence rate of neonatal asphyxia of 11.62%.The neonatal asphyxia group exhibited higher expressions of miR-20 and miR-192 in placental tissues as compared with the neonatal non-asphyxia group;moreover,the proportions of pregnant women with age≥35 years old,who were not completely followed the medical order for treatment,with placental abnormality,with umbilical cord abnormality,with amniotic fluid abnormality,and whose body mass index on the day of delivery were≥30 kg/m2 were higher in the neonatal asphyxia than in the neonatal non-asphyxia group(P<0.05).The results of Logistic regression model analysis revealed that age≥35 years old,completely non-following the medical order for treatment,placental abnormality,umbilical cord abnormality,amniotic fluid abnormality,body mass index on the day of delivery with≥30 kg/m^(2),elevated expressions of miR-20 and miR-192 in placental tissues were all the risk factors for asphyxia in newborns delivered by patients with gestational diabetes mellitus(all P<0.05).Conclusion The expressions of miR-20 and miR-192 in placental tissues of patients with gestational diabetes mellitus are up-regulated,and both of them can cause the increase of the occurrence risk of neona
作者
姚伟妍
唐娟
曾妤平
YAO Wei-yan;TANG Juan;ZENG Yu-ping(Teaching and Researching Section of Gynecology and Obstetrics,School of Nursing,Huizhou Health Science Polytechnic,Huizhou 516000,Guangdong,China;Teaching and Researching Section of Internal Medicine,School of Nursing,Huizhou Health Science Polytechnic,Huizhou 516000,Guangdong,China)
出处
《广西医学》
CAS
2022年第17期1970-1973,共4页
Guangxi Medical Journal
基金
广东省惠州市科技研发计划(2021WC0106473)。
