摘要
目的研究定量骨断层标准摄取值(standardized uptake value,SUV)与骨矿物质密度(bone mineral density,BMD)的相关性。方法回顾性分析了84例于2019年6月1日—2020年2月1日接受骨密度测量及骨断层显像患者的数据,依照BMD结果分为骨质疏松、低骨量和骨量正常共3组,分析不同性别及诊断组间腰椎、股骨颈及全髋T值、BMD、平均SUV(mean SUV,SUVmean)及最大SUV(maximum SUV,SUVmax)差异,并比较SUV与各组数据的相关性。结果男性腰椎BMD、SUVmean及SUVmax均显著高于女性[(1.075±0.191)g/cm^(2) vs(0.950±0.200)g/cm^(2),P=0.004;4.72±0.84 vs 4.23±0.63,P=0.003;9.65±2.10 vs 8.58±1.47,P=0.008]。骨质疏松组腰椎BMD、SUVmean及SUVmax[(0.818±0.080)g/cm^(2),4.26±0.56,8.49±1.52]均显著低于低骨量组[(1.013±0.105)g/cm^(2),4.38±0.70,9.02±1.68]及骨量正常组[(1.264±0.147)g/cm^(2),4.87±1.00,10.03±2.25,P<0.01],腰椎SUVmean及SUVmax与BMD值呈正相关(r=0.451,0.409,P<0.01),而股骨颈和全髋的SUVmean及SUVmax与BMD之间无相关性(P>0.05)。结论骨质疏松症患者腰椎SUV显著降低,且与BMD呈正相关。提示SUV能够在一定程度上反映BMD,为临床提供更多诊断信息。
Objective To investigate the correlation between the standardized uptake value(SUV)of quantitative bone SPECT/CT and bone mineral density(BMD).Methods The clinical data of 84 subjects who received BMD and bone SPECT/CT examination in the same days were analyzed retrospectively.According to the results of BMD,the subjects were divided into osteoporosis,osteopenia and normal groups.The differences of T value,BMD,SUVmean,SUVmax of the lumbar spine,femoral neck and total hip in different genders and diagnosis groups were analyzed.The correlations between SUV and other indicators were studied.Results The values of BMD,SUVmean and SUVmax of lumbar spine in males were significantly higher than those in females(1.075±0.191 g/cm^(2) vs 0.950±0.200 g/cm^(2),P=0.004;4.72±0.84 vs 4.23±0.63,P=0.003;9.65±2.10 vs 8.58±1.47,P=0.008).The osteoporosis group had significantly lower values of BMD,SUVmean and SUVmax of lumbar spine(0.818±0.080 g/cm^(2),4.26±0.56,8.49±1.52)than those of osteopenia group(1.013±0.105 g/cm^(2),4.38±0.70,9.02±1.68)and normal group(1.264±0.147 g/cm^(2),4.87±1.00,10.03±2.25,all P<0.01).The SUVmean and SUVmax of lumbar spine were positively correlated with BMD values(r=0.451,0.409,P<0.01).There was no significantly correlation of SUVmean and SUVmax in femoral neck and whole hip with BMD values(P>0.05).Conclusion The SUV of lumbar spine is markedly declined in patients of osteoporosis,and it is significantly correlated with BMD,indicating that SUV could reflect BMD to a certain extent and may provide more diagnostic information in clinical practice.
作者
孟庆元
王海岩
阳依宏
张新
吴羽
赵军
MENG Qingyuan;WANG Haiyan;YANG Yihong;ZHANG Xin;WU Yu;ZHAO Jun(Department of Nuclear Medicine,Shanghai East Hospital,School of Medicine,Tongji University,Shanghai 200120,China)
出处
《同济大学学报（医学版）》
CAS
2022年第5期690-695,共6页
Journal of Tongji University(Medical Science)
基金
上海市科学技术委员会项目(19DZ1930703)
上海市浦东新区卫生系统重点专科建设项目(PWZzk2017-24)。
关键词
骨定量
标准摄取值
放射性核素显像
骨密度
骨质疏松
bone quantification
standardized uptake value
radionuclide imaging
bone mineral density
osteoporosis
