摘要
目的探讨乳腺癌患者保乳术后血清肿瘤异常蛋白(tumor abnormal protein,TAP)、唾液酸(serum sialic acid,SA)、多肽特异性抗原(tissuepoly peptide specific antigen,TPS)变化及其与远期预后的关系。方法选取2018年1—12月在四川省乐山市人民医院接受保乳术治疗的乳腺癌患者182例,对其进行为期3年随访,记录远期预后情况,并根据是否发生局部复发分为复发组20例和未复发组162例。检测患者术前术后血清TAP、SA、TPS表达水平,探讨其变化情况以及对患者预后的影响。结果两组患者术前TAP聚合物面积、血清SA、TPS差异无显著性(P>0.05);两组患者术后血清TAP聚合物面积、SA、TPS表达均降低,且未复发组低于复发组,差异有显著性(P<0.05);复发组患者手术前后比较,差异无显著性(P>0.05),未复发组手术前后比较,差异有显著性(P<0.05)。两组患者的年龄、肿瘤大小、营养不良、乳腺癌家族史、肿瘤分期差异无显著性(P>0.05),复发组患者淋巴转移、切缘状态阳性发生率高于未复发组(P<0.05),术后规范化疗率低于未复发组(P<0.05)。复发组患者术后TAP聚合物面积大于未复发组(P<0.05),术后血清SA以及TPS浓度高于未复发组(P<0.05)。淋巴转移与乳腺癌患者远期是否发生转移无显著关系(P>0.05),切缘状态阴性、术后规范化疗是术后复发的保护因素(P<0.05),术后血清TAP、SA、TPS高表达是术后复发的危险因素(P<0.05)。乳腺癌患者术后血清TAP、SA、TPS表达水平均与其远期预后存在一定联系,其中术后SA的预测价值最高。结论乳腺癌患者保乳术后血清TAP、SA、TPS均呈降低,但远期预后良好者变化程度更加显著。与此同时,远期预后还与患者术后治疗、手术切缘等因素有关,临床可根据乳腺癌患者血清TAP、SA、TPS保乳术前后表达水平协助预测远期预后情况,对高危患者及时采取干预措施,延长患者生存期。
Objective The aim of this study was to investigate the changes of serum tumor abnormal protein(TAP),sialic acid(SA)and tissue polypeptide specific antigen(TPS)in breast cancer patients after breast conserving surgery,and their relationship with long-term prognosis.Method A total of 182 breast cancer patients who underwent breast-conserving surgery in People’s Hospital of Leshan,Sichuan Province from January to December 2018 were selected as the research subjects.The patients were followed up for 3 years,and the long-term prognosis was recorded.The patients were divided into a recurrence group(n=20)and a non-recurrence group(n=162)according to the presence or absence of local recurrence.Serum TAP,SA and TPS levels were measured before and after surgery.Changes in these serum indicators,and their influence on the prognosis were discussed.Result There was no significant difference in the area of TAP polymer,serum SA or TPS between the two groups before surgery(P>0.05).After surgery,the area of TAP polymer,serum SA and TPS levels in the two groups were decreased,and these indicators in the non-recurrence group were smaller/lower than those in the recurrence group,with significant differences(P<0.05).There was no significant difference in the recurrence group before and after surgery(P>0.05),but there were significant differences in the non-recurrence group before and after surgery(P<0.05).There were no significant differences between the two groups in terms of age,tumor size,malnutrition,family history of breast cancer,and tumor stage(P>0.05).The incidence rates of lymph node metastasis and positive margin in the recurrence group were higher than those in the non-recurrence group(P<0.05),and the rate of postoperative standard chemotherapy was lower than that in the non-recurrence group(P<0.05).After surgery,the area of TAP polymer in the recurrence group was larger than that in the non-recurrence group(P<0.05),and serum SA and TPS levels were higher than those in the non-recurrence group(P<0.05).There was no signif
作者
黄亮
李远平
祝琴
董鹏
HUANG Liang;LI Yuanping;ZHU Qin;DONG Peng(Department of Breast and Thyroid Surgery,People’s Hospital of Leshan,Leshan 614000,Leshan Sichuan,China)
出处
《中国临床医生杂志》
2022年第11期1286-1289,共4页
Chinese Journal For Clinicians
基金
四川省医学会科研课题(S18045)
四川省乐山市科技计划指导性项目(18SZD160)。
关键词
乳腺癌
保乳术
肿瘤异常蛋白
唾液酸
多肽特异性抗原
远期预后
Breast cancer
Breast conserving surgery
Abnormal tumor protein
Sialic acid
Tissue polypeptide specific antigen
Long-term prognosis
